Tracers and Imaging of Fatty Acid and Energy Metabolism of Human Adipose Tissues

White adipose tissue and brown adipose tissue (WAT and BAT) regulate fatty acid metabolism and control lipid fluxes to other organs. Dysfunction of these key metabolic processes contributes to organ insulin resistance and inflammation leading to chronic diseases such as type 2 diabetes, metabolic dy...

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Bibliographic Details
Published in:Physiology (Bethesda, Md.) Md.), 2024-03, Vol.39 (2), p.0-72
Main Author: Carpentier, André C
Format: Article
Language:English
Subjects:
Adipose Tissue, Brown - diagnostic imaging
Adipose Tissue, Brown - metabolism
Adipose Tissue, White - metabolism
Diabetes Mellitus, Type 2 - metabolism
Energy Metabolism - physiology
Fatty Acids - metabolism
Humans
Review
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Summary:White adipose tissue and brown adipose tissue (WAT and BAT) regulate fatty acid metabolism and control lipid fluxes to other organs. Dysfunction of these key metabolic processes contributes to organ insulin resistance and inflammation leading to chronic diseases such as type 2 diabetes, metabolic dysfunction-associated steatohepatitis, and cardiovascular diseases. Metabolic tracers combined with molecular imaging methods are powerful tools for the investigation of these pathogenic mechanisms. Herein, I review some of the positron emission tomography and magnetic resonance imaging methods combined with stable isotopic metabolic tracers to investigate fatty acid and energy metabolism, focusing on human WAT and BAT metabolism. I will discuss the complementary strengths offered by these methods for human investigations and current gaps in the field.
ISSN:1548-9213
1548-9221
1548-9221
DOI:10.1152/physiol.00012.2023