A silicon diode-based optoelectronic interface for bidirectional neural modulation

• Published in: Proceedings of the National Academy of Sciences - PNAS 2024-07, Vol.121 (30), p.e2404164121
• Main Authors: Fu, Xin, Hu, Zhengwei, Li, Wenjun, Ma, Liang, Chen, Junyu, Liu, Muyang, Liu, Jie, Hu, Shuhan, Wang, Huachun, Huang, Yunxiang, Tang, Guo, Zhang, Bozhen, Cai, Xue, Wang, Yuqi, Li, Lizhu, Ma, Jian, Shi, Song-Hai, Yin, Lan, Zhang, Hao, Li, Xiaojian, Sheng, Xing
• Format: Article
• Language: English
• Subjects: Animals; Brain - physiology; Calcium; Calcium (intracellular); Calcium - metabolism; Calcium signalling; Depolarization; In vivo methods and tests; Irradiation; Light; Mice; Modulation; Nervous system; Neuromodulation; Neurons - physiology; Optoelectronic devices; Optogenetics - methods; Physical Sciences; Power management; Silicon; Silicon - chemistry; Silicon diodes; Thin films
• ISSN: 0027-8424; 1091-6490; 1091-6490
• DOI: 10.1073/pnas.2404164121

The development of advanced neural modulation techniques is crucial to neuroscience research and neuroengineering applications. Recently, optical-based, nongenetic modulation approaches have been actively investigated to remotely interrogate the nervous system with high precision. Here, we show that a thin-film, silicon (Si)-based diode device is capable to bidirectionally regulate in vitro and in vivo neural activities upon adjusted illumination. When exposed to high-power and short-pulsed light, the Si diode generates photothermal effects, evoking neuron depolarization and enhancing intracellular calcium dynamics. Conversely, low-power and long-pulsed light on the Si diode hyperpolarizes neurons and reduces calcium activities. Furthermore, the Si diode film mounted on the brain of living mice can activate or suppress cortical activities under varied irradiation conditions. The presented material and device strategies reveal an innovated optoelectronic interface for precise neural modulations.