Loading…
Prevotella diversity, niches and interactions with the human host
The genus Prevotella includes more than 50 characterized species that occur in varied natural habitats, although most Prevotella spp. are associated with humans. In the human microbiome, Prevotella spp. are highly abundant in various body sites, where they are key players in the balance between heal...
Saved in:
| Published in: | Nature reviews. Microbiology 2021-09, Vol.19 (9), p.585-599 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c591t-d7677ec6a5370c1d64c81541f848757b826d1164bcb4dd05663ac7e9514131913 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c591t-d7677ec6a5370c1d64c81541f848757b826d1164bcb4dd05663ac7e9514131913 |
| container_end_page | 599 |
| container_issue | 9 |
| container_start_page | 585 |
| container_title | Nature reviews. Microbiology |
| container_volume | 19 |
| creator | Tett, Adrian Pasolli, Edoardo Masetti, Giulia Ercolini, Danilo Segata, Nicola |
| description | The genus
Prevotella
includes more than 50 characterized species that occur in varied natural habitats, although most
Prevotella
spp. are associated with humans. In the human microbiome,
Prevotella
spp. are highly abundant in various body sites, where they are key players in the balance between health and disease. Host factors related to diet, lifestyle and geography are fundamental in affecting the diversity and prevalence of
Prevotella
species and strains in the human microbiome. These factors, along with the ecological relationship of
Prevotella
with other members of the microbiome, likely determine the extent of the contribution of
Prevotella
to human metabolism and health. Here we review the diversity, prevalence and potential connection of
Prevotella
spp. in the human host, highlighting how genomic methods and analysis have improved and should further help in framing their ecological role. We also provide suggestions for future research to improve understanding of the possible functions of
Prevotella
spp. and the effects of the Western lifestyle and diet on the host–
Prevotella
symbiotic relationship in the context of maintaining human health.
Prevotella
is a genus of bacteria that commonly associate with humans, in various body sites. In this Review, Segata, Ercolini and colleagues discuss
Prevotella
diversity and the evidence for the involvement of these bacteria in human health and disease. |
| doi_str_mv | 10.1038/s41579-021-00559-y |
| format | article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11290707</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A671651304</galeid><sourcerecordid>A671651304</sourcerecordid><originalsourceid>FETCH-LOGICAL-c591t-d7677ec6a5370c1d64c81541f848757b826d1164bcb4dd05663ac7e9514131913</originalsourceid><addsrcrecordid>eNp9UU2LFDEUDKK46-gf8CANXjzYa14-u08yLH7Bgh70HDJJejpLd7Im6ZH592acddYVkRwS8qrqUVUIPQd8AZh2bzIDLvsWE2gx5rxv9w_QOUiGW-CUPTy9iThDT3K-xphwLsljdEYZ5piS7hytvyS3i8VNk26s37mUfdm_boI3o8uNDrbxobikTfEx5OaHL2NTRteMy6xDM8ZcnqJHg56ye3Z7r9C39---Xn5srz5_-HS5vmoN76G0VgopnRGaU4kNWMFMB5zB0LFOcrnpiLAAgm3MhlmLuRBUG-l6Dgwo9EBX6O1R92bZzM4aF0rSk7pJftZpr6L26v4k-FFt404BkB5LLKvCq1uFFL8vLhc1-2wO1oOLS1akpiYAoEazQi__gl7HJYXqr6IErrkTQe5QWz055cMQ62JzEFVrIUFwoJhV1MU_UPVYN3sTgxt8_b9HIEeCSTHn5IaTScDq0Lw6Nq9q8-pX82pfSS_-jOdE-V11BdAjINdR2Lp0Z-k_sj8B8U23Nw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2560157262</pqid></control><display><type>article</type><title>Prevotella diversity, niches and interactions with the human host</title><source>Nature</source><creator>Tett, Adrian ; Pasolli, Edoardo ; Masetti, Giulia ; Ercolini, Danilo ; Segata, Nicola</creator><creatorcontrib>Tett, Adrian ; Pasolli, Edoardo ; Masetti, Giulia ; Ercolini, Danilo ; Segata, Nicola</creatorcontrib><description>The genus
Prevotella
includes more than 50 characterized species that occur in varied natural habitats, although most
Prevotella
spp. are associated with humans. In the human microbiome,
Prevotella
spp. are highly abundant in various body sites, where they are key players in the balance between health and disease. Host factors related to diet, lifestyle and geography are fundamental in affecting the diversity and prevalence of
Prevotella
species and strains in the human microbiome. These factors, along with the ecological relationship of
Prevotella
with other members of the microbiome, likely determine the extent of the contribution of
Prevotella
to human metabolism and health. Here we review the diversity, prevalence and potential connection of
Prevotella
spp. in the human host, highlighting how genomic methods and analysis have improved and should further help in framing their ecological role. We also provide suggestions for future research to improve understanding of the possible functions of
Prevotella
spp. and the effects of the Western lifestyle and diet on the host–
Prevotella
symbiotic relationship in the context of maintaining human health.
Prevotella
is a genus of bacteria that commonly associate with humans, in various body sites. In this Review, Segata, Ercolini and colleagues discuss
Prevotella
diversity and the evidence for the involvement of these bacteria in human health and disease.</description><identifier>ISSN: 1740-1526</identifier><identifier>ISSN: 1740-1534</identifier><identifier>EISSN: 1740-1534</identifier><identifier>DOI: 10.1038/s41579-021-00559-y</identifier><identifier>PMID: 34050328</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/326/2565/2134 ; 631/326/2565/855 ; 631/326/41/2142 ; 631/61/212/2306 ; 692/308/174 ; Autoimmune Diseases - microbiology ; Bacteria ; Bacteroidaceae Infections - microbiology ; Biological diversity ; Biomedical and Life Sciences ; Diet ; Disease ; Disease susceptibility ; Genetic Variation ; Genomes ; Geography ; Gram-negative bacteria ; Host-bacteria relationships ; Humans ; Infectious Diseases ; Life Sciences ; Lifestyles ; Medical Microbiology ; Microbiological research ; Microbiology ; Microbiomes ; Microbiota ; Observations ; Parasitology ; Phylogenetics ; Phylogeny ; Physiological aspects ; Prevotella ; Prevotella - classification ; Prevotella - genetics ; Prevotella - physiology ; Review Article ; Virology ; Westernization</subject><ispartof>Nature reviews. Microbiology, 2021-09, Vol.19 (9), p.585-599</ispartof><rights>Springer Nature Limited 2021</rights><rights>2021. Springer Nature Limited.</rights><rights>COPYRIGHT 2021 Nature Publishing Group</rights><rights>Springer Nature Limited 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c591t-d7677ec6a5370c1d64c81541f848757b826d1164bcb4dd05663ac7e9514131913</citedby><cites>FETCH-LOGICAL-c591t-d7677ec6a5370c1d64c81541f848757b826d1164bcb4dd05663ac7e9514131913</cites><orcidid>0000-0002-1583-5794 ; 0000-0002-8513-2509 ; 0000-0003-3061-9560</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34050328$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tett, Adrian</creatorcontrib><creatorcontrib>Pasolli, Edoardo</creatorcontrib><creatorcontrib>Masetti, Giulia</creatorcontrib><creatorcontrib>Ercolini, Danilo</creatorcontrib><creatorcontrib>Segata, Nicola</creatorcontrib><title>Prevotella diversity, niches and interactions with the human host</title><title>Nature reviews. Microbiology</title><addtitle>Nat Rev Microbiol</addtitle><addtitle>Nat Rev Microbiol</addtitle><description>The genus
Prevotella
includes more than 50 characterized species that occur in varied natural habitats, although most
Prevotella
spp. are associated with humans. In the human microbiome,
Prevotella
spp. are highly abundant in various body sites, where they are key players in the balance between health and disease. Host factors related to diet, lifestyle and geography are fundamental in affecting the diversity and prevalence of
Prevotella
species and strains in the human microbiome. These factors, along with the ecological relationship of
Prevotella
with other members of the microbiome, likely determine the extent of the contribution of
Prevotella
to human metabolism and health. Here we review the diversity, prevalence and potential connection of
Prevotella
spp. in the human host, highlighting how genomic methods and analysis have improved and should further help in framing their ecological role. We also provide suggestions for future research to improve understanding of the possible functions of
Prevotella
spp. and the effects of the Western lifestyle and diet on the host–
Prevotella
symbiotic relationship in the context of maintaining human health.
Prevotella
is a genus of bacteria that commonly associate with humans, in various body sites. In this Review, Segata, Ercolini and colleagues discuss
Prevotella
diversity and the evidence for the involvement of these bacteria in human health and disease.</description><subject>631/326/2565/2134</subject><subject>631/326/2565/855</subject><subject>631/326/41/2142</subject><subject>631/61/212/2306</subject><subject>692/308/174</subject><subject>Autoimmune Diseases - microbiology</subject><subject>Bacteria</subject><subject>Bacteroidaceae Infections - microbiology</subject><subject>Biological diversity</subject><subject>Biomedical and Life Sciences</subject><subject>Diet</subject><subject>Disease</subject><subject>Disease susceptibility</subject><subject>Genetic Variation</subject><subject>Genomes</subject><subject>Geography</subject><subject>Gram-negative bacteria</subject><subject>Host-bacteria relationships</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Life Sciences</subject><subject>Lifestyles</subject><subject>Medical Microbiology</subject><subject>Microbiological research</subject><subject>Microbiology</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Observations</subject><subject>Parasitology</subject><subject>Phylogenetics</subject><subject>Phylogeny</subject><subject>Physiological aspects</subject><subject>Prevotella</subject><subject>Prevotella - classification</subject><subject>Prevotella - genetics</subject><subject>Prevotella - physiology</subject><subject>Review Article</subject><subject>Virology</subject><subject>Westernization</subject><issn>1740-1526</issn><issn>1740-1534</issn><issn>1740-1534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9UU2LFDEUDKK46-gf8CANXjzYa14-u08yLH7Bgh70HDJJejpLd7Im6ZH592acddYVkRwS8qrqUVUIPQd8AZh2bzIDLvsWE2gx5rxv9w_QOUiGW-CUPTy9iThDT3K-xphwLsljdEYZ5piS7hytvyS3i8VNk26s37mUfdm_boI3o8uNDrbxobikTfEx5OaHL2NTRteMy6xDM8ZcnqJHg56ye3Z7r9C39---Xn5srz5_-HS5vmoN76G0VgopnRGaU4kNWMFMB5zB0LFOcrnpiLAAgm3MhlmLuRBUG-l6Dgwo9EBX6O1R92bZzM4aF0rSk7pJftZpr6L26v4k-FFt404BkB5LLKvCq1uFFL8vLhc1-2wO1oOLS1akpiYAoEazQi__gl7HJYXqr6IErrkTQe5QWz055cMQ62JzEFVrIUFwoJhV1MU_UPVYN3sTgxt8_b9HIEeCSTHn5IaTScDq0Lw6Nq9q8-pX82pfSS_-jOdE-V11BdAjINdR2Lp0Z-k_sj8B8U23Nw</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Tett, Adrian</creator><creator>Pasolli, Edoardo</creator><creator>Masetti, Giulia</creator><creator>Ercolini, Danilo</creator><creator>Segata, Nicola</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1583-5794</orcidid><orcidid>https://orcid.org/0000-0002-8513-2509</orcidid><orcidid>https://orcid.org/0000-0003-3061-9560</orcidid></search><sort><creationdate>20210901</creationdate><title>Prevotella diversity, niches and interactions with the human host</title><author>Tett, Adrian ; Pasolli, Edoardo ; Masetti, Giulia ; Ercolini, Danilo ; Segata, Nicola</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c591t-d7677ec6a5370c1d64c81541f848757b826d1164bcb4dd05663ac7e9514131913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>631/326/2565/2134</topic><topic>631/326/2565/855</topic><topic>631/326/41/2142</topic><topic>631/61/212/2306</topic><topic>692/308/174</topic><topic>Autoimmune Diseases - microbiology</topic><topic>Bacteria</topic><topic>Bacteroidaceae Infections - microbiology</topic><topic>Biological diversity</topic><topic>Biomedical and Life Sciences</topic><topic>Diet</topic><topic>Disease</topic><topic>Disease susceptibility</topic><topic>Genetic Variation</topic><topic>Genomes</topic><topic>Geography</topic><topic>Gram-negative bacteria</topic><topic>Host-bacteria relationships</topic><topic>Humans</topic><topic>Infectious Diseases</topic><topic>Life Sciences</topic><topic>Lifestyles</topic><topic>Medical Microbiology</topic><topic>Microbiological research</topic><topic>Microbiology</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Observations</topic><topic>Parasitology</topic><topic>Phylogenetics</topic><topic>Phylogeny</topic><topic>Physiological aspects</topic><topic>Prevotella</topic><topic>Prevotella - classification</topic><topic>Prevotella - genetics</topic><topic>Prevotella - physiology</topic><topic>Review Article</topic><topic>Virology</topic><topic>Westernization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tett, Adrian</creatorcontrib><creatorcontrib>Pasolli, Edoardo</creatorcontrib><creatorcontrib>Masetti, Giulia</creatorcontrib><creatorcontrib>Ercolini, Danilo</creatorcontrib><creatorcontrib>Segata, Nicola</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature reviews. Microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tett, Adrian</au><au>Pasolli, Edoardo</au><au>Masetti, Giulia</au><au>Ercolini, Danilo</au><au>Segata, Nicola</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevotella diversity, niches and interactions with the human host</atitle><jtitle>Nature reviews. Microbiology</jtitle><stitle>Nat Rev Microbiol</stitle><addtitle>Nat Rev Microbiol</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>19</volume><issue>9</issue><spage>585</spage><epage>599</epage><pages>585-599</pages><issn>1740-1526</issn><issn>1740-1534</issn><eissn>1740-1534</eissn><abstract>The genus
Prevotella
includes more than 50 characterized species that occur in varied natural habitats, although most
Prevotella
spp. are associated with humans. In the human microbiome,
Prevotella
spp. are highly abundant in various body sites, where they are key players in the balance between health and disease. Host factors related to diet, lifestyle and geography are fundamental in affecting the diversity and prevalence of
Prevotella
species and strains in the human microbiome. These factors, along with the ecological relationship of
Prevotella
with other members of the microbiome, likely determine the extent of the contribution of
Prevotella
to human metabolism and health. Here we review the diversity, prevalence and potential connection of
Prevotella
spp. in the human host, highlighting how genomic methods and analysis have improved and should further help in framing their ecological role. We also provide suggestions for future research to improve understanding of the possible functions of
Prevotella
spp. and the effects of the Western lifestyle and diet on the host–
Prevotella
symbiotic relationship in the context of maintaining human health.
Prevotella
is a genus of bacteria that commonly associate with humans, in various body sites. In this Review, Segata, Ercolini and colleagues discuss
Prevotella
diversity and the evidence for the involvement of these bacteria in human health and disease.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34050328</pmid><doi>10.1038/s41579-021-00559-y</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-1583-5794</orcidid><orcidid>https://orcid.org/0000-0002-8513-2509</orcidid><orcidid>https://orcid.org/0000-0003-3061-9560</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1740-1526 |
| ispartof | Nature reviews. Microbiology, 2021-09, Vol.19 (9), p.585-599 |
| issn | 1740-1526 1740-1534 1740-1534 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11290707 |
| source | Nature |
| subjects | 631/326/2565/2134 631/326/2565/855 631/326/41/2142 631/61/212/2306 692/308/174 Autoimmune Diseases - microbiology Bacteria Bacteroidaceae Infections - microbiology Biological diversity Biomedical and Life Sciences Diet Disease Disease susceptibility Genetic Variation Genomes Geography Gram-negative bacteria Host-bacteria relationships Humans Infectious Diseases Life Sciences Lifestyles Medical Microbiology Microbiological research Microbiology Microbiomes Microbiota Observations Parasitology Phylogenetics Phylogeny Physiological aspects Prevotella Prevotella - classification Prevotella - genetics Prevotella - physiology Review Article Virology Westernization |
| title | Prevotella diversity, niches and interactions with the human host |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T03%3A11%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prevotella%20diversity,%20niches%20and%20interactions%20with%20the%20human%20host&rft.jtitle=Nature%20reviews.%20Microbiology&rft.au=Tett,%20Adrian&rft.date=2021-09-01&rft.volume=19&rft.issue=9&rft.spage=585&rft.epage=599&rft.pages=585-599&rft.issn=1740-1526&rft.eissn=1740-1534&rft_id=info:doi/10.1038/s41579-021-00559-y&rft_dat=%3Cgale_pubme%3EA671651304%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c591t-d7677ec6a5370c1d64c81541f848757b826d1164bcb4dd05663ac7e9514131913%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2560157262&rft_id=info:pmid/34050328&rft_galeid=A671651304&rfr_iscdi=true |