Predicting posttraumatic epilepsy using admission electroencephalography after severe traumatic brain injury

• Published in: Epilepsia (Copenhagen) 2023-07, Vol.64 (7), p.1842-1852
• Main Authors: Pease, Matthew, Elmer, Jonathan, Shahabadi, Ameneh Zare, Mallela, Arka N., Ruiz‐Rodriguez, Juan F., Sexton, Daniel, Barot, Niravkumar, Gonzalez‐Martinez, Jorge A., Shutter, Lori, Okonkwo, David O., Castellano, James F.
• Format: Article
• Language: English
• Subjects: Brain Injuries, Traumatic - complications; Brain Injuries, Traumatic - diagnosis; Case-Control Studies; Clinical trials; EEG; Electroencephalography; Epilepsy; Epilepsy, Post-Traumatic - diagnosis; Epilepsy, Post-Traumatic - etiology; Glasgow Coma Scale; Humans; posttraumatic epilepsy; Prediction models; Regression analysis; seizures; Statistical analysis; Traumatic brain injury
• ISSN: 0013-9580; 1528-1167; 1528-1167
• DOI: 10.1111/epi.17622

Objective Posttraumatic epilepsy (PTE) develops in as many as one third of severe traumatic brain injury (TBI) patients, often years after injury. Analysis of early electroencephalographic (EEG) features, by both standardized visual interpretation (viEEG) and quantitative EEG (qEEG) analysis, may aid early identification of patients at high risk for PTE. Methods We performed a case–control study using a prospective database of severe TBI patients treated at a single center from 2011 to 2018. We identified patients who survived 2 years postinjury and matched patients with PTE to those without using age and admission Glasgow Coma Scale score. A neuropsychologist recorded outcomes at 1 year using the Expanded Glasgow Outcomes Scale (GOSE). All patients underwent continuous EEG for 3–5 days. A board‐certified epileptologist, blinded to outcomes, described viEEG features using standardized descriptions. We extracted 14 qEEG features from an early 5‐min epoch, described them using qualitative statistics, then developed two multivariable models to predict long‐term risk of PTE (random forest and logistic regression). Results We identified 27 patients with and 35 without PTE. GOSE scores were similar at 1 year (p = .93). The median time to onset of PTE was 7.2 months posttrauma (interquartile range = 2.2–22.2 months). None of the viEEG features was different between the groups. On qEEG, the PTE cohort had higher spectral power in the delta frequencies, more power variance in the delta and theta frequencies, and higher peak envelope (all p