Age- and Gender-Specific Reference Intervals for the Fasting Serum Lipid Levels in a Pediatric Population Aged 0–＜15 Years in Nanjing, China

• Published in: Journal of Atherosclerosis and Thrombosis 2024/08/01, Vol.31(8), pp.1135-1148
• Main Authors: Yu, Hanqing, Li, Chenli, Guo, Min, Yang, Yanli, Gui, Zhen, Chang, Yong
• Format: Article
• Language: English
• Subjects: Adolescent; Age Factors; Child; Child, Preschool; China - epidemiology; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Dyslipidemia; Fasting - blood; Female; Humans; Infant; Infant, Newborn; Lipids - blood; Male; Original; Pediatric; Reference Intervals; Reference Values; Serum lipids; Sex Factors; Triglycerides - blood
• ISSN: 1340-3478; 1880-3873; 1880-3873
• DOI: 10.5551/jat.64270

Aims: The lipid reference intervals (RIs) that are currently used for children in China are not based on studies of the local population and normally do not consider age or gender differences. This study aimed to establish age- and sex-specific RIs for the fasting serum lipid levels in the pediatric population aged 0 – 15 years in Nanjing, China.Methods: 5,866 children aged 3 days to ＜15 years were recruited to establish serum lipid RIs, and the triglyceride (TG), total cholesterol (TC), and high-density lipoprotein cholesterol (HDL-C) levels were analyzed using the Roche cobas702 automatic biochemical analyzer. Low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (nHDL-C) levels were calculated (LDL-C=TC−HDL-C−TG/5, and nHDL-C=TC−HDL-C). Smoothed percentile curves for the boys and girls were generated using the LMS method. Age- and sex-specific RIs were the determined according to the methods recommended by the Clinical and Laboratory Standards Institute EP28-A3c guidelines.Results: This study showed that the serum lipid levels varied considerably throughout childhood and adolescence, with sex differences, especially in infants aged less than 2 years and puberty. Based on the Harris-Boyd method, sex partitions were required for ages ＜6 months in the TC indicator and for ages ≤ 28 days in LDL-C and nHDL-C. Age partitions were also required for all serum lipid parameters.Conclusions: We established age- and sex-specific RIs for TG, TC, HDL-C, LDL-C, and nHDL-C parameters in children aged 0 days to ＜15 years in Nanjing, China. These data are thus considered to be useful for the screening of dyslipidemia in children and adolescents.