Prenatal Screening for and Prevalence of Hepatitis B Surface Antigen in Pregnant Women and Prevention of Transmission to Infants Born to Infected Mothers-Guam, 2014

• Published in: Journal of the Pediatric Infectious Diseases Society 2018-12, Vol.7 (4), p.290-295
• Main Authors: Abara, Winston E, Cha, Susan, Malik, Tasneem, DeSimone, Mia S, Schillie, Sarah, Collier, Melissa, Schumann, Bernadette, Klemme, Michael, Kamb, Mary
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Endemic Diseases - prevention & control; Female; Guam - epidemiology; Hepatitis B - diagnosis; Hepatitis B - epidemiology; Hepatitis B - prevention & control; Hepatitis B - transmission; Hepatitis B Surface Antigens - blood; Hepatitis B Vaccines - therapeutic use; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical - prevention & control; Neonatal Screening; Post-Exposure Prophylaxis; Pregnancy; Pregnancy Complications, Infectious - diagnosis; Pregnancy Complications, Infectious - epidemiology; Pregnancy Complications, Infectious - prevention & control; Prenatal Care - standards; Prevalence; Young Adult
• ISSN: 2048-7193; 2048-7207; 2048-7207
• DOI: 10.1093/jpids/pix062

Perinatal transmission is the major mode of hepatitis B virus (HBV) transmission and drives HBV endemicity in the US territory of Guam. We assessed correlates of prenatal hepatitis B surface antigen (HBsAg) screening and HBsAg positivity among pregnant women and evaluated the care of infants of HBsAg-positive women. Demographic and clinical data were abstracted from the maternal medical records of 966 randomly selected live infants born in 2014. Frequencies were calculated, and prevalence ratios (PRs) and 95% confidence intervals (CIs) were estimated using Poisson regression. Among the mothers of the 966 infants, 78.2% were Pacific Islanders, 56.9% were >25 years old (born before universal infant hepatitis B vaccination in Guam), 89.0% received prenatal care (PNC), 96.7% underwent prenatal HBsAg screening, and 2.0% were HBsAg positive. Approximately 15% of the women who did not have PNC were not screened for HBsAg. Receipt of PNC was associated with HBsAg screening (adjusted PR, 1.13 [95% CI, 1.04-1.23]), and HBsAg positivity was associated with a maternal age of >25 years (adjusted PR, 6.80 [95% CI, 1.32-35.08]). All 18 infants of the HBsAg-positive mothers received hepatitis B vaccine, and 17 (94.4%) received hepatitis B immunoglobulin. Although the prenatal HBsAg screening prevalence in this sample was high, the maternal HBsAg prevalence among women in this sample was more than 14 times and 2 times the prevalence among US-born Pacific Islander/Asian women and all women in the continental United States, respectively. Improving access to PNC, ensuring that all pregnant women in Guam (especially those born before universal hepatitis B vaccination) are screened for HBsAg, and adopting postexposure prophylaxis for infants of HBsAg-positive mothers as standard clinical practice are important for preventing perinatal HBV transmission and reducing HBV endemicity.