Clinical case analysis of 32 children aged 0–6 years with lead poisoning in Nanning, China

• Published in: Toxicology and industrial health 2024-02, Vol.40 (1-2), p.41-51
• Main Authors: Wei, Yi-fei, Gan, Cui-liu, Xu, Fang, Fang, Yuan-yuan, Zhang, Bao-dan, Li, Wu-shu, Nong, Kang, Aschner, Michael, Jiang, Yue-ming
• Format: Article
• Language: English
• Subjects: Appetite loss; Blood levels; Blood-brain barrier; Child; Children; China - epidemiology; Constipation; Diarrhea; Edetic Acid; Ethylenediaminetetraacetic acids; Health services; Heavy metals; Hematocrit; Hemoglobin; Hemoglobins; Herbal medicine; Hospitals; Humans; Hyperactivity; Immune system; Infant; Lead - toxicity; Lead content; Lead poisoning; Lead Poisoning - epidemiology; Lead Poisoning - etiology; Poisoning; Renal function; Risk factors; β2 Microglobulin
• ISSN: 0748-2337; 1477-0393; 1477-0393
• DOI: 10.1177/07482337231215411

Lead is one of the heavy metals that is toxic and widely distributed in the environment, and children are more sensitive to the toxic effects of lead because the blood–brain barrier and immune system are not yet well developed. The objective of the study was to investigate the clinical characteristics of lead poisoning in children aged 0∼6 years in a hospital in Guangxi, and to provide scientific basis for the prevention and treatment of lead poisoning. We collected and analyzed the clinical data of 32 children with lead poisoning admitted to a hospital in Guangxi from 2010 to 2018. The results showed that most of the 32 cases presented with hyperactivity, irritability, poor appetite, abdominal pain, diarrhea, or constipation. The hemoglobin (HGB), mean corpusular volume (MCV), mean corpuscular hemoglobin (MCH), and hematocrit (HCT) of the lead-poisoned children were all decreased to different degrees and were below normal acceptable levels. Urinary β2-microglobulin was increased. Blood lead levels (BLL) decreased significantly after intravenous injection of the lead chelator, calcium disodium edetate (CaNa2-EDTA). In addition, HGB returned to normal levels, while MCV, MCH, and HCT increased but remained below normal levels. Urinary β2-microglobulin was reduced to normal levels. Therefore, in this cohort of children, the high-risk factors for lead poisoning are mainly Chinese medicines, such as baby powder. In conclusion, lead poisoning caused neurological damage and behavioral changes in children and decreased erythrocyte parameters, leading to digestive symptoms and renal impairment, which can be attenuated by CaNa2-EDTA treatment.