Unraveling the Tau Puzzle: A Brief Discussion on Biomarkers in Alzheimer’s Disease

This commentary provides an in-depth analysis of a recently published systematic review on ‘Biomarkers of Tau Pathology in Alzheimer’s Disease’, elucidating insights into its implications for the field. This meta-analysis highlights the potential of plasma and CSF p-tau 181/231 as promising, non-inv...

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Bibliographic Details
Published in:Journal of Alzheimer's disease 2024-06, Vol.100 (1), p.41-43
Main Authors: Cantero-Fortiz, Yahveth, Cano, Amanda, Boada, Mercè
Format: Article
Language:English
Subjects:
Alzheimer Disease - blood
Alzheimer Disease - cerebrospinal fluid
Alzheimer Disease - diagnosis
Alzheimer's disease
Biomarkers
Biomarkers - blood
Biomarkers - cerebrospinal fluid
Cerebrospinal fluid
Humans
Isoforms
Meta-analysis
Neurodegenerative diseases
Precision medicine
Systematic Reviews as Topic
Tau protein
tau Proteins - blood
tau Proteins - cerebrospinal fluid
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Summary:This commentary provides an in-depth analysis of a recently published systematic review on ‘Biomarkers of Tau Pathology in Alzheimer’s Disease’, elucidating insights into its implications for the field. This meta-analysis highlights the potential of plasma and CSF p-tau 181/231 as promising, non-invasive, and cost-effective diagnostic tools for patients suffering from AD continuum. The study comprehensively reviews the diagnostic potential of these p-tau isoforms, shedding light on their role in the precision diagnosis of Alzheimer’s disease. Here we discuss the significance of these findings and the methodological nuances, emphasizing broader implications for advancing personalized medicine in neurodegenerative disorders.
ISSN:1387-2877
1875-8908
1875-8908
DOI:10.3233/JAD-240055