Mycobacterium bovis Infection of a Deep Brain Stimulation System Following Intravesical Bacillus Calmette-Guérin (BCG) Instillation

Deep brain stimulation (DBS) is an advanced treatment in Parkinson’s disease. We describe a 71-year-old patient in whom the DBS got infected with Mycobacterium bovis shortly after intravesical BCG instillations as an adjuvant treatment of bladder cancer. The DBS internal pulse generator and extensio...

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Bibliographic Details
Published in:Journal of Parkinson's disease 2024-01, Vol.14 (5), p.1061-1069
Main Authors: Spruijt, Linda E., Mosch, Arne, Hoffmann, Carel F.E., van Nieuwkoop, Cees, Tijsterman, Jasper D., Zutt, Rodi, van der Gaag, Niels A., Contarino, M. Fiorella
Format: Article
Language:English
Subjects:
Bacillus Calmette-Guerin vaccine
BCG
Case Report
Deep brain stimulation
Ethambutol
Isoniazid
Mycobacterium bovis
Neurodegenerative diseases
Parkinson's disease
Rifampin
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Summary:Deep brain stimulation (DBS) is an advanced treatment in Parkinson’s disease. We describe a 71-year-old patient in whom the DBS got infected with Mycobacterium bovis shortly after intravesical BCG instillations as an adjuvant treatment of bladder cancer. The DBS internal pulse generator and extension wires had to be replaced, and the patient was treated successfully with rifampicin, isoniazid, and ethambutol during three months. This case suggests that physicians need to be aware of the risk of this kind of infection and add a specific Mycobacterial test to the regular cultures.
ISSN:1877-7171
1877-718X
DOI:10.3233/JPD-230426