Seroreversion to Chlamydia trachomatis Pgp3 Antigen Among Children in a Hyperendemic Region of Amhara, Ethiopia

Abstract Monitoring trachoma transmission with antibody data requires characterization of decay in IgG to Chlamydia trachomatis antigens. In a 3-year longitudinal cohort in a high-transmission setting, we estimated a median IgG half-life of 3 years and a seroreversion rate of 2.5 per 100 person-year...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of infectious diseases 2024-08, Vol.230 (2), p.293-297
Main Authors: Tedijanto, Christine, Aragie, Solomon, Gwyn, Sarah, Wittberg, Dionna M, Zeru, Taye, Tadesse, Zerihun, Chernet, Ambahun, Thompson, Isabel J B, Nash, Scott D, Lietman, Thomas M, Martin, Diana L, Keenan, Jeremy D, Arnold, Benjamin F
Format: Article
Language:English
Subjects:
Antibodies, Bacterial - blood
Antibodies, Bacterial - immunology
Antigens, Bacterial - immunology
Bacterial Proteins - immunology
Brief Report
Child
Child, Preschool
Chlamydia trachomatis
Chlamydia trachomatis - immunology
Clinical trials
Endemic Diseases
Ethiopia - epidemiology
Female
Humans
Immunoglobulin G
Immunoglobulin G - blood
Immunoglobulin G - immunology
Infant
Longitudinal Studies
Male
Trachoma
Trachoma - epidemiology
Trachoma - immunology
Trachoma - microbiology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Monitoring trachoma transmission with antibody data requires characterization of decay in IgG to Chlamydia trachomatis antigens. In a 3-year longitudinal cohort in a high-transmission setting, we estimated a median IgG half-life of 3 years and a seroreversion rate of 2.5 per 100 person-years (95% confidence interval, 1.6–3.5). Clinical Trials Registration NCT02754583.
ISSN:0022-1899
1537-6613
1537-6613
DOI:10.1093/infdis/jiad602