Loading…
Ferritin is a potential marker of cardiometabolic risk in adolescents and young adults with sleep-disordered breathing
To explore markers that reflect sleep-disordered breathing (SDB) severity and investigate their associations with cardiometabolic risk factors in adolescents and young adults. Participants were recruited from our SDB epidemiological cohort. They underwent overnight polysomnography and ambulatory blo...
Saved in:
| Published in: | Sleep advances. 2024, Vol.5 (1), p.zpae048 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c2058-bd8740030009603048f455f0afc5a351dc9a722cdbcf74ff359a590da755ada63 |
| container_end_page | |
| container_issue | 1 |
| container_start_page | zpae048 |
| container_title | Sleep advances. |
| container_volume | 5 |
| creator | Cheng, Esther T W Au, Chun T Chan, Raymond N C Chan, Joey W Y Chan, Ngan Y Wing, Yun K Li, Albert M Lam, Ethan Chan, Kate C |
| description | To explore markers that reflect sleep-disordered breathing (SDB) severity and investigate their associations with cardiometabolic risk factors in adolescents and young adults.
Participants were recruited from our SDB epidemiological cohort. They underwent overnight polysomnography and ambulatory blood pressure (BP) monitoring. Complete blood count, ferritin, high-sensitivity C-reactive protein (hs-CRP), fasting blood glucose, and lipid profile were measured. Multiple linear regression was used to examine the association between red cell indices (RCIs), ferritin, and obstructive apnea-hypopnea index (OAHI). Subgroup analyses on participants with SDB were performed for the association of RCIs and ferritin with lipid profile, hs-CRP, and BP.
There were 88 participants with SDB and 155 healthy controls aged 16-25 years. Hemoglobin (Hb;
|
| doi_str_mv | 10.1093/sleepadvances/zpae048 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11331151</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3094823639</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2058-bd8740030009603048f455f0afc5a351dc9a722cdbcf74ff359a590da755ada63</originalsourceid><addsrcrecordid>eNpVUU1PGzEQtVARRIGfQOVjL1vs9Xo_TlUVlYIUiUt7tmbtcWJw1lt7NxX8-poSUDjNaOa9mTfzCLni7CtnnbhOHnEEs4dBY7p-HgFZ1Z6QRVmLspCMl5-O8nNymdIDY6yUXNSCn5Fz0fGaN1W9IPsbjNFNbqAuUaBjmHCYHHi6g_iIkQZLNUTjwg4n6IN3mkaXHmkmgAkek874zBwMfQrzsMnV2efCXzdt6X-ZhXEpRIMRDe0jwrR1w-aCnFrwCS8PcUl-3_z4tbot1vc_71bf14UumWyL3rRNxZjI4rs6h6q1lZSWgdUShORGd9CUpTa9tk1lrZAdyI4ZaKQEA7VYkm-vc8e536F5ERvBqzG6fN-TCuDUx87gtmoT9opzITjPD1uSL4cJMfyZMU1q5_LR3sOAYU5KsK5qy_zXLkPlK1THkFJE-76HM_Xim_rgmzr4lnmfj0W-s95cEv8A5cec1g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3094823639</pqid></control><display><type>article</type><title>Ferritin is a potential marker of cardiometabolic risk in adolescents and young adults with sleep-disordered breathing</title><source>PubMed Central</source><source>Oxford Academic Journals (Open Access)</source><creator>Cheng, Esther T W ; Au, Chun T ; Chan, Raymond N C ; Chan, Joey W Y ; Chan, Ngan Y ; Wing, Yun K ; Li, Albert M ; Lam, Ethan ; Chan, Kate C</creator><creatorcontrib>Cheng, Esther T W ; Au, Chun T ; Chan, Raymond N C ; Chan, Joey W Y ; Chan, Ngan Y ; Wing, Yun K ; Li, Albert M ; Lam, Ethan ; Chan, Kate C</creatorcontrib><description><![CDATA[To explore markers that reflect sleep-disordered breathing (SDB) severity and investigate their associations with cardiometabolic risk factors in adolescents and young adults.
Participants were recruited from our SDB epidemiological cohort. They underwent overnight polysomnography and ambulatory blood pressure (BP) monitoring. Complete blood count, ferritin, high-sensitivity C-reactive protein (hs-CRP), fasting blood glucose, and lipid profile were measured. Multiple linear regression was used to examine the association between red cell indices (RCIs), ferritin, and obstructive apnea-hypopnea index (OAHI). Subgroup analyses on participants with SDB were performed for the association of RCIs and ferritin with lipid profile, hs-CRP, and BP.
There were 88 participants with SDB and 155 healthy controls aged 16-25 years. Hemoglobin (Hb;
< .001), hematocrit (HCT;
< .001), and ferritin (
< .001) were elevated with increasing SDB severity and were independently associated with OAHI (β=1.06,
< .001;
=40.2,
< .001;
=4.89 × 10
,
= .024, respectively). In participants with SDB, after adjusting for age, sex, and BMI, significant associations were found between ferritin with low-density lipoprotein (LDL;
=0.936 × 10
,
= .008) and triglyceride (TG;
=1.08 × 10
,
< .001), as well as between Hb (
=1.40,
= .007), HCT (
=51.5,
= .010) and mean arterial pressure (MAP). Ferritin (
=0.091,
= .002), Hb (
=0.975,
= .005), and HCT (
=38.8,
= .004) were associated with hs-CRP independent of age, sex, BMI, plasma LDL, and MAP. OAHI was not associated with LDL and TG in the multivariable models.
Serum ferritin, but not OAHI, was associated with LDL and TG in participants with SDB, suggesting it is a potential marker of cardiometabolic risk in patients with SDB.]]></description><identifier>ISSN: 2632-5012</identifier><identifier>EISSN: 2632-5012</identifier><identifier>DOI: 10.1093/sleepadvances/zpae048</identifier><identifier>PMID: 39161746</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Original</subject><ispartof>Sleep advances., 2024, Vol.5 (1), p.zpae048</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of Sleep Research Society.</rights><rights>The Author(s) 2024. Published by Oxford University Press on behalf of Sleep Research Society. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2058-bd8740030009603048f455f0afc5a351dc9a722cdbcf74ff359a590da755ada63</cites><orcidid>0000-0001-7405-4560 ; 0000-0001-7272-8285 ; 0000-0003-0572-2777 ; 0000-0002-2692-2666 ; 0000-0002-5745-5474</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331151/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11331151/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4009,27902,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39161746$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Esther T W</creatorcontrib><creatorcontrib>Au, Chun T</creatorcontrib><creatorcontrib>Chan, Raymond N C</creatorcontrib><creatorcontrib>Chan, Joey W Y</creatorcontrib><creatorcontrib>Chan, Ngan Y</creatorcontrib><creatorcontrib>Wing, Yun K</creatorcontrib><creatorcontrib>Li, Albert M</creatorcontrib><creatorcontrib>Lam, Ethan</creatorcontrib><creatorcontrib>Chan, Kate C</creatorcontrib><title>Ferritin is a potential marker of cardiometabolic risk in adolescents and young adults with sleep-disordered breathing</title><title>Sleep advances.</title><addtitle>Sleep Adv</addtitle><description><![CDATA[To explore markers that reflect sleep-disordered breathing (SDB) severity and investigate their associations with cardiometabolic risk factors in adolescents and young adults.
Participants were recruited from our SDB epidemiological cohort. They underwent overnight polysomnography and ambulatory blood pressure (BP) monitoring. Complete blood count, ferritin, high-sensitivity C-reactive protein (hs-CRP), fasting blood glucose, and lipid profile were measured. Multiple linear regression was used to examine the association between red cell indices (RCIs), ferritin, and obstructive apnea-hypopnea index (OAHI). Subgroup analyses on participants with SDB were performed for the association of RCIs and ferritin with lipid profile, hs-CRP, and BP.
There were 88 participants with SDB and 155 healthy controls aged 16-25 years. Hemoglobin (Hb;
< .001), hematocrit (HCT;
< .001), and ferritin (
< .001) were elevated with increasing SDB severity and were independently associated with OAHI (β=1.06,
< .001;
=40.2,
< .001;
=4.89 × 10
,
= .024, respectively). In participants with SDB, after adjusting for age, sex, and BMI, significant associations were found between ferritin with low-density lipoprotein (LDL;
=0.936 × 10
,
= .008) and triglyceride (TG;
=1.08 × 10
,
< .001), as well as between Hb (
=1.40,
= .007), HCT (
=51.5,
= .010) and mean arterial pressure (MAP). Ferritin (
=0.091,
= .002), Hb (
=0.975,
= .005), and HCT (
=38.8,
= .004) were associated with hs-CRP independent of age, sex, BMI, plasma LDL, and MAP. OAHI was not associated with LDL and TG in the multivariable models.
Serum ferritin, but not OAHI, was associated with LDL and TG in participants with SDB, suggesting it is a potential marker of cardiometabolic risk in patients with SDB.]]></description><subject>Original</subject><issn>2632-5012</issn><issn>2632-5012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpVUU1PGzEQtVARRIGfQOVjL1vs9Xo_TlUVlYIUiUt7tmbtcWJw1lt7NxX8-poSUDjNaOa9mTfzCLni7CtnnbhOHnEEs4dBY7p-HgFZ1Z6QRVmLspCMl5-O8nNymdIDY6yUXNSCn5Fz0fGaN1W9IPsbjNFNbqAuUaBjmHCYHHi6g_iIkQZLNUTjwg4n6IN3mkaXHmkmgAkek874zBwMfQrzsMnV2efCXzdt6X-ZhXEpRIMRDe0jwrR1w-aCnFrwCS8PcUl-3_z4tbot1vc_71bf14UumWyL3rRNxZjI4rs6h6q1lZSWgdUShORGd9CUpTa9tk1lrZAdyI4ZaKQEA7VYkm-vc8e536F5ERvBqzG6fN-TCuDUx87gtmoT9opzITjPD1uSL4cJMfyZMU1q5_LR3sOAYU5KsK5qy_zXLkPlK1THkFJE-76HM_Xim_rgmzr4lnmfj0W-s95cEv8A5cec1g</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Cheng, Esther T W</creator><creator>Au, Chun T</creator><creator>Chan, Raymond N C</creator><creator>Chan, Joey W Y</creator><creator>Chan, Ngan Y</creator><creator>Wing, Yun K</creator><creator>Li, Albert M</creator><creator>Lam, Ethan</creator><creator>Chan, Kate C</creator><general>Oxford University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7405-4560</orcidid><orcidid>https://orcid.org/0000-0001-7272-8285</orcidid><orcidid>https://orcid.org/0000-0003-0572-2777</orcidid><orcidid>https://orcid.org/0000-0002-2692-2666</orcidid><orcidid>https://orcid.org/0000-0002-5745-5474</orcidid></search><sort><creationdate>2024</creationdate><title>Ferritin is a potential marker of cardiometabolic risk in adolescents and young adults with sleep-disordered breathing</title><author>Cheng, Esther T W ; Au, Chun T ; Chan, Raymond N C ; Chan, Joey W Y ; Chan, Ngan Y ; Wing, Yun K ; Li, Albert M ; Lam, Ethan ; Chan, Kate C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2058-bd8740030009603048f455f0afc5a351dc9a722cdbcf74ff359a590da755ada63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Esther T W</creatorcontrib><creatorcontrib>Au, Chun T</creatorcontrib><creatorcontrib>Chan, Raymond N C</creatorcontrib><creatorcontrib>Chan, Joey W Y</creatorcontrib><creatorcontrib>Chan, Ngan Y</creatorcontrib><creatorcontrib>Wing, Yun K</creatorcontrib><creatorcontrib>Li, Albert M</creatorcontrib><creatorcontrib>Lam, Ethan</creatorcontrib><creatorcontrib>Chan, Kate C</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Sleep advances.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Esther T W</au><au>Au, Chun T</au><au>Chan, Raymond N C</au><au>Chan, Joey W Y</au><au>Chan, Ngan Y</au><au>Wing, Yun K</au><au>Li, Albert M</au><au>Lam, Ethan</au><au>Chan, Kate C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ferritin is a potential marker of cardiometabolic risk in adolescents and young adults with sleep-disordered breathing</atitle><jtitle>Sleep advances.</jtitle><addtitle>Sleep Adv</addtitle><date>2024</date><risdate>2024</risdate><volume>5</volume><issue>1</issue><spage>zpae048</spage><pages>zpae048-</pages><issn>2632-5012</issn><eissn>2632-5012</eissn><abstract><![CDATA[To explore markers that reflect sleep-disordered breathing (SDB) severity and investigate their associations with cardiometabolic risk factors in adolescents and young adults.
Participants were recruited from our SDB epidemiological cohort. They underwent overnight polysomnography and ambulatory blood pressure (BP) monitoring. Complete blood count, ferritin, high-sensitivity C-reactive protein (hs-CRP), fasting blood glucose, and lipid profile were measured. Multiple linear regression was used to examine the association between red cell indices (RCIs), ferritin, and obstructive apnea-hypopnea index (OAHI). Subgroup analyses on participants with SDB were performed for the association of RCIs and ferritin with lipid profile, hs-CRP, and BP.
There were 88 participants with SDB and 155 healthy controls aged 16-25 years. Hemoglobin (Hb;
< .001), hematocrit (HCT;
< .001), and ferritin (
< .001) were elevated with increasing SDB severity and were independently associated with OAHI (β=1.06,
< .001;
=40.2,
< .001;
=4.89 × 10
,
= .024, respectively). In participants with SDB, after adjusting for age, sex, and BMI, significant associations were found between ferritin with low-density lipoprotein (LDL;
=0.936 × 10
,
= .008) and triglyceride (TG;
=1.08 × 10
,
< .001), as well as between Hb (
=1.40,
= .007), HCT (
=51.5,
= .010) and mean arterial pressure (MAP). Ferritin (
=0.091,
= .002), Hb (
=0.975,
= .005), and HCT (
=38.8,
= .004) were associated with hs-CRP independent of age, sex, BMI, plasma LDL, and MAP. OAHI was not associated with LDL and TG in the multivariable models.
Serum ferritin, but not OAHI, was associated with LDL and TG in participants with SDB, suggesting it is a potential marker of cardiometabolic risk in patients with SDB.]]></abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>39161746</pmid><doi>10.1093/sleepadvances/zpae048</doi><orcidid>https://orcid.org/0000-0001-7405-4560</orcidid><orcidid>https://orcid.org/0000-0001-7272-8285</orcidid><orcidid>https://orcid.org/0000-0003-0572-2777</orcidid><orcidid>https://orcid.org/0000-0002-2692-2666</orcidid><orcidid>https://orcid.org/0000-0002-5745-5474</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2632-5012 |
| ispartof | Sleep advances., 2024, Vol.5 (1), p.zpae048 |
| issn | 2632-5012 2632-5012 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11331151 |
| source | PubMed Central; Oxford Academic Journals (Open Access) |
| subjects | Original |
| title | Ferritin is a potential marker of cardiometabolic risk in adolescents and young adults with sleep-disordered breathing |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T10%3A14%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ferritin%20is%20a%20potential%20marker%20of%20cardiometabolic%20risk%20in%20adolescents%20and%20young%20adults%20with%20sleep-disordered%20breathing&rft.jtitle=Sleep%20advances.&rft.au=Cheng,%20Esther%20T%20W&rft.date=2024&rft.volume=5&rft.issue=1&rft.spage=zpae048&rft.pages=zpae048-&rft.issn=2632-5012&rft.eissn=2632-5012&rft_id=info:doi/10.1093/sleepadvances/zpae048&rft_dat=%3Cproquest_pubme%3E3094823639%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c2058-bd8740030009603048f455f0afc5a351dc9a722cdbcf74ff359a590da755ada63%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3094823639&rft_id=info:pmid/39161746&rfr_iscdi=true |