The impact of augmenter of liver regeneration in blunt liver trauma: An experimental model analysis

BACKGROUND: Traumatic liver injury is an acute event that triggers liver repair. The augmenter of liver regeneration (ALR) has been identified as a growth factor involved in this process. This study evaluates the impact of ALR on isolated liver blunt trauma and examines its relationship with various...

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Bibliographic Details
Published in:Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 2024-07, Vol.30 (7), p.472-479
Main Authors: Kavak, Nezih, Akcan, Gulben, Balci, Nurgul, Suer, Aziz Ahmet, Guler, Ilkay, Kavak, Rasime Pelin
Format: Article
Language:English
Subjects:
Analysis
Euthanasia
Experimental Study
Inflammation
Liver
Liver diseases
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Summary:BACKGROUND: Traumatic liver injury is an acute event that triggers liver repair. The augmenter of liver regeneration (ALR) has been identified as a growth factor involved in this process. This study evaluates the impact of ALR on isolated liver blunt trauma and examines its relationship with various time intervals. METHODS: Forty healthy female Wistar albino rats were divided into five groups (n=8 each). Isolated blunt liver trauma was induced using a custom-designed trauma platform in all groups except for Group 1. The groups were categorized by the timing of euthanasia post-trauma: 2nd (15 minutes), 3rd (30 minutes), 4th (45 minutes), and 5th (60 minutes). Assessments included plasma ALR levels, liver tissue ALR levels (both intact and lacerated), biochemical indices, and liver histological analysis. RESULTS: Plasma ALR levels in Group 4 were higher than in Groups 1 and 2 (p
ISSN:1306-696X
1307-7945
DOI:10.14744/tjtes.2024.92575