Receptor binding, internalization, and retrograde transport of neurotrophic factors

This review deals with the receptor interactions of neurotrophic factors, focusing on the neurotrophins of the nerve growth factor (NGF) family, the glial cell derived neurotrophic factor (GDNF) family, and the ciliary neurotrophic factor (CNTF) family. The finding that two proteins, p75NTR and Trk,...

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Bibliographic Details
Published in:Cellular and molecular life sciences : CMLS 2001-07, Vol.58 (8), p.1021-1035
Main Authors: Neet, K E, Campenot, R B
Format: Article
Language:English
Subjects:
Animals
Biological Transport, Active
Cellular biology
Humans
Kinases
Nerve Growth Factors - metabolism
Neurology
Neurons
Protein Binding
Protein Transport
Proteins
Receptor, Nerve Growth Factor - metabolism
Receptor, trkA - metabolism
Receptors, Nerve Growth Factor - metabolism
Signal Transduction
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Summary:This review deals with the receptor interactions of neurotrophic factors, focusing on the neurotrophins of the nerve growth factor (NGF) family, the glial cell derived neurotrophic factor (GDNF) family, and the ciliary neurotrophic factor (CNTF) family. The finding that two proteins, p75NTR and Trk, act as receptors for NGF in neurons generated the discovery of other neurotrophic factors/receptor families and has enhanced our understanding of the development, survival, regeneration, and degeneration of the nervous system. The kinetics of binding, the structure of the ligand-receptor complex, and the mechanism of retrograde transport of the neurotrophins are discussed in detail and compared to information available on the GDNF and CNTF families. Each neurotrophic factor family, i.e., NGF, GDNF, and CNTF, has a set of receptors with specificity for individual members of the family and a common receptor without member specificity that, in some families, generates the cellular signal and retrograde transport.
ISSN:1420-682X
1420-9071
DOI:10.1007/PL00000917