Design and Synthesis of CdHgSe/HgS/CdZnS Core/Multi-Shell Quantum Dots Exhibiting High-Quantum-Yield Tissue-Penetrating Shortwave Infrared Luminescence

• Published in: Small (Weinheim an der Bergstrasse, Germany) Germany), 2023-09, Vol.19 (36), p.e2301161-e2301161
• Main Authors: Lee, Gyudong, Jeong, Woo Hyeon, Kim, Beomjoo, Jeon, Sungwoong, Smith, Andrew M, Seo, Jongcheol, Suzuki, Kengo, Kim, Jin-Young, Lee, Hyunki, Choi, Hongsoo, Chung, Dae Sung, Choi, Jongmin, Choi, Hyosung, Lim, Sung Jun
• Format: Article
• Language: English
• Subjects: Composite materials; Energy gap; Nanotechnology; Photoluminescence; Quantum dots; Short wave radiation
• ISSN: 1613-6810; 1613-6829; 1613-6829
• DOI: 10.1002/smll.202301161

Cd Hg Se/HgS/Cd Zn S core/multi-shell quantum dots (QDs) exhibiting bright tissue-penetrating shortwave infrared (SWIR; 1000-1700 nm) photoluminescence (PL) are engineered. The new structure consists of a quasi-type-II Cd Hg Se/HgS core/inner shell domain creating luminescent bandgap tunable across SWIR window and a wide-bandgap Cd Zn S outer shell boosting the PL quantum yield (QY). This compositional sequence also facilitates uniform and coherent shell growth by minimizing interfacial lattice mismatches, resulting in high QYs in both organic (40-80%) and aqueous (20-70%) solvents with maximum QYs of 87 and 73%, respectively, which are comparable to those of brightest visible-to-near infrared QDs. Moreover, they maintain bright PL in a photocurable resin (QY 40%, peak wavelength ≈ 1300 nm), enabling the fabrication of SWIR-luminescent composites of diverse morphology and concentration. These composites are used to localize controlled amounts of SWIR QDs inside artificial (Intralipid) and porcine tissues and quantitatively evaluate the applicability as luminescent probes for deep-tissue imaging.