LncRNA MEG3 Restrains Hepatic Lipogenesis via the FOXO1 Signaling Pathway in HepG2 Cells

Nonalcoholic fatty liver disease (NAFLD) become a main public health concern, and is characterized by lipid accumulation in the hepatocytes. We found that overexpression of lncRNA MEG3 significantly reduced the expression of FOXO1, ACC1, and FAS, and subsequently decreased the lipid accumulation in...

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Bibliographic Details
Published in:Cell biochemistry and biophysics 2024-06, Vol.82 (2), p.1253-1259
Main Authors: Meng, Xiangyu, Long, Mei, Yue, Nanxi, Li, Quan, Chen, Jia, Zhao, Hongye, Deng, Wei
Format: Article
Language:English
Subjects:
Accumulation
Adenoviruses
Antibodies
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biotechnology
Cell Biology
Fatty acids
Fatty liver
Forkhead Box Protein O1 - genetics
Forkhead Box Protein O1 - metabolism
FOXO1 protein
Hep G2 Cells
Hepatocytes
Hospitals
Humans
Inflammation
Insulin resistance
Kinases
Life Sciences
Lipids
Lipogenesis
Liver - metabolism
Liver diseases
Metabolic disorders
Metabolism
mRNA
Non-alcoholic Fatty Liver Disease - genetics
Non-alcoholic Fatty Liver Disease - metabolism
Non-alcoholic Fatty Liver Disease - pathology
Non-coding RNA
Original Paper
Pharmacology/Toxicology
Proteins
Public health
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Signal Transduction
Therapeutic targets
Translocation
Triglycerides
Tumor necrosis factor-TNF
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Summary:Nonalcoholic fatty liver disease (NAFLD) become a main public health concern, and is characterized by lipid accumulation in the hepatocytes. We found that overexpression of lncRNA MEG3 significantly reduced the expression of FOXO1, ACC1, and FAS, and subsequently decreased the lipid accumulation in HepG2 cells. Moreover, inhibition of lncRNA MEG3 could increase the lipid accumulation and the mRNA and protein levels of FOXO1, ACC1, and FAS. Further study showed that lncRNA MEG3 regulates the lipogenesis process by inhibiting the entry of FOXO1 into the nucleus translocation. Our study demonstrated that lncRNA MEG3 regulates de novo lipogenesis by decreasing the expression and nucleus translocation of FOXO1 in HepG2 cells, suggesting that lncRNA MEG3 could be a promising therapeutic target in lipid metabolic disorders.
ISSN:1085-9195
1559-0283
1559-0283
DOI:10.1007/s12013-024-01278-w