Risk Factors of Chemotherapy-Induced Thrombocytopenia After Oxaliplatin-Containing Chemotherapy for Gastrointestinal Malignancies

Purpose Thrombocytopenia is among the most common chemotherapy-related hematologic toxicities. We aim to determine the predictors of oxaliplatin chemotherapy-induced thrombocytopenia in patients with gastrointestinal tumors to guide the clinic. Methods Clinical data of 750 patients with a malignant...

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Published in:Journal of gastrointestinal cancer 2024-09, Vol.55 (3), p.1144-1153
Main Authors: Li, Ju, Wang, Wanqing, Jiang, Kaipeng, Cui, Jiuwei, Wang, Chang, Liang, Tingting, Wang, Yizhuo, Liu, Shuhan, Zhou, Wenshuo
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Language:English
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Cancer Research
Gastroenterology
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Radiotherapy
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container_end_page 1153
container_issue 3
container_start_page 1144
container_title Journal of gastrointestinal cancer
container_volume 55
creator Li, Ju
Wang, Wanqing
Jiang, Kaipeng
Cui, Jiuwei
Wang, Chang
Liang, Tingting
Wang, Yizhuo
Liu, Shuhan
Zhou, Wenshuo
description Purpose Thrombocytopenia is among the most common chemotherapy-related hematologic toxicities. We aim to determine the predictors of oxaliplatin chemotherapy-induced thrombocytopenia in patients with gastrointestinal tumors to guide the clinic. Methods Clinical data of 750 patients with a malignant gastrointestinal tumor were included as the primary cohort. Basic clinical data, serological indices, and anthropometric indices of these patients were collected. According to the presence or absence of CIT, univariate analysis was performed to identify significant factors for multivariate analysis. In R language software, nomogram was constructed based on the results of multi-factor analysis, and the calibration curve and ROC curve were drawn. Results Univariate analysis identified 17 factors as closely related to CIT occurrence, namely age, lymph node metastasis (N) stage, metastasis (M) stage, lung metastasis, other site metastasis, chemotherapy regimen, course of treatment, total dose of oxaliplatin, AST, albumin, neutrophils, monocytes, baseline platelets, transferrin, natural killer (NK) cell, phase angle, and SMI ( P  
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We aim to determine the predictors of oxaliplatin chemotherapy-induced thrombocytopenia in patients with gastrointestinal tumors to guide the clinic. Methods Clinical data of 750 patients with a malignant gastrointestinal tumor were included as the primary cohort. Basic clinical data, serological indices, and anthropometric indices of these patients were collected. According to the presence or absence of CIT, univariate analysis was performed to identify significant factors for multivariate analysis. In R language software, nomogram was constructed based on the results of multi-factor analysis, and the calibration curve and ROC curve were drawn. Results Univariate analysis identified 17 factors as closely related to CIT occurrence, namely age, lymph node metastasis (N) stage, metastasis (M) stage, lung metastasis, other site metastasis, chemotherapy regimen, course of treatment, total dose of oxaliplatin, AST, albumin, neutrophils, monocytes, baseline platelets, transferrin, natural killer (NK) cell, phase angle, and SMI ( P  &lt; 0.10). The binary logistic multivariate regression analysis revealed five independent risk factors for developing CIT ( P  &lt; 0.05), including the M stage, total dose of oxaliplatin, albumin, baseline thrombocyte count, and NK cell. Based on the results of multivariate logistic regression analysis, R software was used to establish a nomogram model. The calibration curve shows that the combined predictor has good consistency. The area under the ROC curve was 0.877 and the best cut-off value was 0.3579613 (sensitivity, 78.9%; specificity, 81.8%), which showed the better prediction efficiency. Conclusion The total dose of oxaliplatin, M stage, albumin, baseline platelet count, and NK cell was independent risk factors for CIT. The sequentially constructed histogram model had a good predictive effect on the risk of thrombocytopenia caused by oxaliplatin chemotherapy in patients with gastrointestinal malignancies.</description><identifier>ISSN: 1941-6628</identifier><identifier>ISSN: 1941-6636</identifier><identifier>EISSN: 1941-6636</identifier><identifier>DOI: 10.1007/s12029-024-01059-x</identifier><identifier>PMID: 38713434</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cancer Research ; Gastroenterology ; Internal Medicine ; Medicine ; Medicine &amp; Public Health ; Oncology ; Radiotherapy</subject><ispartof>Journal of gastrointestinal cancer, 2024-09, Vol.55 (3), p.1144-1153</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c398t-7944116d5113e4cebb658746913150377368cc12740ae642339be211d185a5593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38713434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Ju</creatorcontrib><creatorcontrib>Wang, Wanqing</creatorcontrib><creatorcontrib>Jiang, Kaipeng</creatorcontrib><creatorcontrib>Cui, Jiuwei</creatorcontrib><creatorcontrib>Wang, Chang</creatorcontrib><creatorcontrib>Liang, Tingting</creatorcontrib><creatorcontrib>Wang, Yizhuo</creatorcontrib><creatorcontrib>Liu, Shuhan</creatorcontrib><creatorcontrib>Zhou, Wenshuo</creatorcontrib><title>Risk Factors of Chemotherapy-Induced Thrombocytopenia After Oxaliplatin-Containing Chemotherapy for Gastrointestinal Malignancies</title><title>Journal of gastrointestinal cancer</title><addtitle>J Gastrointest Canc</addtitle><addtitle>J Gastrointest Cancer</addtitle><description>Purpose Thrombocytopenia is among the most common chemotherapy-related hematologic toxicities. We aim to determine the predictors of oxaliplatin chemotherapy-induced thrombocytopenia in patients with gastrointestinal tumors to guide the clinic. Methods Clinical data of 750 patients with a malignant gastrointestinal tumor were included as the primary cohort. Basic clinical data, serological indices, and anthropometric indices of these patients were collected. According to the presence or absence of CIT, univariate analysis was performed to identify significant factors for multivariate analysis. In R language software, nomogram was constructed based on the results of multi-factor analysis, and the calibration curve and ROC curve were drawn. Results Univariate analysis identified 17 factors as closely related to CIT occurrence, namely age, lymph node metastasis (N) stage, metastasis (M) stage, lung metastasis, other site metastasis, chemotherapy regimen, course of treatment, total dose of oxaliplatin, AST, albumin, neutrophils, monocytes, baseline platelets, transferrin, natural killer (NK) cell, phase angle, and SMI ( P  &lt; 0.10). The binary logistic multivariate regression analysis revealed five independent risk factors for developing CIT ( P  &lt; 0.05), including the M stage, total dose of oxaliplatin, albumin, baseline thrombocyte count, and NK cell. Based on the results of multivariate logistic regression analysis, R software was used to establish a nomogram model. The calibration curve shows that the combined predictor has good consistency. The area under the ROC curve was 0.877 and the best cut-off value was 0.3579613 (sensitivity, 78.9%; specificity, 81.8%), which showed the better prediction efficiency. Conclusion The total dose of oxaliplatin, M stage, albumin, baseline platelet count, and NK cell was independent risk factors for CIT. The sequentially constructed histogram model had a good predictive effect on the risk of thrombocytopenia caused by oxaliplatin chemotherapy in patients with gastrointestinal malignancies.</description><subject>Cancer Research</subject><subject>Gastroenterology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Oncology</subject><subject>Radiotherapy</subject><issn>1941-6628</issn><issn>1941-6636</issn><issn>1941-6636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kU1vFCEYx4mxsXX1C3gwc_SC8gwMDCfTbGxtUtOkqWfCMMwudQZGYMzusd-86NaNvXiC5Pm_8PBD6B2Qj0CI-JSgJrXEpGaYAGkk3r1AZyAZYM4pf3m81-0pep3SPSGcNQCv0CltBVBG2Rl6uHXpR3WhTQ4xVWGo1ls7hby1Uc97fOX7xdi-utvGMHXB7HOYrXe6Oh-yjdXNTo9uHnV2Hq-Dz9p55zfPIqohxOpSpxyD89mmItVj9a34Nl5742x6g04GPSb79ulcoe8XX-7WX_H1zeXV-vwaGyrbjIVkDID3ZQFqmbFdx5tWMC6BQkOoEJS3xkAtGNGWs5pS2dkaoIe20U0j6Qp9PuTOSzfZ3lifox7VHN2k414F7dTziXdbtQm_VClkgpWCFfrwlBDDz6XsoiaXjB1H7W1YkqKkAUklCF6k9UFqYkgp2uHYA0T9hqcO8FSBp_7AU7tiev_vC4-Wv7SKgB4EqYz8xkZ1H5ZYPjT9L_YRSXeoZw</recordid><startdate>20240901</startdate><enddate>20240901</enddate><creator>Li, Ju</creator><creator>Wang, Wanqing</creator><creator>Jiang, Kaipeng</creator><creator>Cui, Jiuwei</creator><creator>Wang, Chang</creator><creator>Liang, Tingting</creator><creator>Wang, Yizhuo</creator><creator>Liu, Shuhan</creator><creator>Zhou, Wenshuo</creator><general>Springer US</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20240901</creationdate><title>Risk Factors of Chemotherapy-Induced Thrombocytopenia After Oxaliplatin-Containing Chemotherapy for Gastrointestinal Malignancies</title><author>Li, Ju ; Wang, Wanqing ; Jiang, Kaipeng ; Cui, Jiuwei ; Wang, Chang ; Liang, Tingting ; Wang, Yizhuo ; Liu, Shuhan ; Zhou, Wenshuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-7944116d5113e4cebb658746913150377368cc12740ae642339be211d185a5593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cancer Research</topic><topic>Gastroenterology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Oncology</topic><topic>Radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Ju</creatorcontrib><creatorcontrib>Wang, Wanqing</creatorcontrib><creatorcontrib>Jiang, Kaipeng</creatorcontrib><creatorcontrib>Cui, Jiuwei</creatorcontrib><creatorcontrib>Wang, Chang</creatorcontrib><creatorcontrib>Liang, Tingting</creatorcontrib><creatorcontrib>Wang, Yizhuo</creatorcontrib><creatorcontrib>Liu, Shuhan</creatorcontrib><creatorcontrib>Zhou, Wenshuo</creatorcontrib><collection>SpringerOpen</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of gastrointestinal cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Ju</au><au>Wang, Wanqing</au><au>Jiang, Kaipeng</au><au>Cui, Jiuwei</au><au>Wang, Chang</au><au>Liang, Tingting</au><au>Wang, Yizhuo</au><au>Liu, Shuhan</au><au>Zhou, Wenshuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk Factors of Chemotherapy-Induced Thrombocytopenia After Oxaliplatin-Containing Chemotherapy for Gastrointestinal Malignancies</atitle><jtitle>Journal of gastrointestinal cancer</jtitle><stitle>J Gastrointest Canc</stitle><addtitle>J Gastrointest Cancer</addtitle><date>2024-09-01</date><risdate>2024</risdate><volume>55</volume><issue>3</issue><spage>1144</spage><epage>1153</epage><pages>1144-1153</pages><issn>1941-6628</issn><issn>1941-6636</issn><eissn>1941-6636</eissn><abstract>Purpose Thrombocytopenia is among the most common chemotherapy-related hematologic toxicities. We aim to determine the predictors of oxaliplatin chemotherapy-induced thrombocytopenia in patients with gastrointestinal tumors to guide the clinic. Methods Clinical data of 750 patients with a malignant gastrointestinal tumor were included as the primary cohort. Basic clinical data, serological indices, and anthropometric indices of these patients were collected. According to the presence or absence of CIT, univariate analysis was performed to identify significant factors for multivariate analysis. In R language software, nomogram was constructed based on the results of multi-factor analysis, and the calibration curve and ROC curve were drawn. Results Univariate analysis identified 17 factors as closely related to CIT occurrence, namely age, lymph node metastasis (N) stage, metastasis (M) stage, lung metastasis, other site metastasis, chemotherapy regimen, course of treatment, total dose of oxaliplatin, AST, albumin, neutrophils, monocytes, baseline platelets, transferrin, natural killer (NK) cell, phase angle, and SMI ( P  &lt; 0.10). The binary logistic multivariate regression analysis revealed five independent risk factors for developing CIT ( P  &lt; 0.05), including the M stage, total dose of oxaliplatin, albumin, baseline thrombocyte count, and NK cell. Based on the results of multivariate logistic regression analysis, R software was used to establish a nomogram model. The calibration curve shows that the combined predictor has good consistency. The area under the ROC curve was 0.877 and the best cut-off value was 0.3579613 (sensitivity, 78.9%; specificity, 81.8%), which showed the better prediction efficiency. Conclusion The total dose of oxaliplatin, M stage, albumin, baseline platelet count, and NK cell was independent risk factors for CIT. The sequentially constructed histogram model had a good predictive effect on the risk of thrombocytopenia caused by oxaliplatin chemotherapy in patients with gastrointestinal malignancies.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38713434</pmid><doi>10.1007/s12029-024-01059-x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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subjects Cancer Research
Gastroenterology
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Radiotherapy
title Risk Factors of Chemotherapy-Induced Thrombocytopenia After Oxaliplatin-Containing Chemotherapy for Gastrointestinal Malignancies
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