Maximizing Success: An Overview of Optimizing the Ovarian Tissue Transplantation Site

Ovarian tissue cryopreservation and transplantation (OTCT) has emerged in recent years as a potential method for reversing abnormal endocrine and reproductive functions, particularly in patients receiving gonadotoxic cancer treatments having longer survival rates. From its first rodent experiments t...

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Bibliographic Details
Published in:JBRA assisted reproduction 2024-01, Vol.28 (3), p.497-502
Main Authors: Saçıntı, Koray Görkem, Sadat, Rowaida, Özkavukçu, Sinan, Sonmezer, Meltem, Sönmezer, Murat
Format: Article
Language:English
Subjects:
Angiogenesis
Cancer therapies
Cryopreservation
Cryopreservation - methods
Female
Fertility
Fertility Preservation - methods
Follicles
General anesthesia
Humans
Ischemia
Laparoscopy
Life expectancy
Ovaries
Ovary - transplantation
Pregnancy
Reproductive health
Reproductive technologies
Retroperitoneal Space - surgery
Review
Success
Surgery
Transplants & implants
Vascular endothelial growth factor
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Summary:Ovarian tissue cryopreservation and transplantation (OTCT) has emerged in recent years as a potential method for reversing abnormal endocrine and reproductive functions, particularly in patients receiving gonadotoxic cancer treatments having longer survival rates. From its first rodent experiments to human trials, OTCT has evolved tremendously, opening new windows for further utilization. Since then, significant progress has been achieved in terms of techniques used for surgical removal of the tissue, optimal fragment size, freezing and thawing procedures, and appropriate surgical sites for the subsequent reimplementation of the graft. In addition, various approaches have been proposed to decrease the risk of ischemic injury, which is the leading cause of significant follicle loss during neo-angiogenesis. This review aims to discuss the pros and cons of ovarian and retroperitoneal transplantation sites, highlighting the justifications for the viability and efficacy of different transplantation sites as well as the potential advantages and drawbacks of retroperitoneal or preperitoneal area.
ISSN:1518-0557
1517-5693
1518-0557
DOI:10.5935/1518-0557.20240027