Neuropsychiatric symptom burden in early‐onset and late‐onset Alzheimer's disease as a function of age

INTRODUCTION We examined the burden of neuropsychiatric symptoms (NPSs) in early‐onset (EO) and late‐onset (LO) Alzheimer's disease (AD) and adjusted for age effects via the inclusion of cognitively unimpaired (CU) individuals. METHODS Cross‐sectional data from 2940 EOAD, 8665 LOAD, and 8775 ag...

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Published in:Alzheimer's & dementia 2024-08, Vol.20 (8), p.5481-5491
Main Authors: Polsinelli, Angelina J., Johnson, Sierah, Crouch, Adele, Lane, Kathleen A., Pena‐Garcia, Alex, Hammers, Dustin B., Wang, Sophia, Gao, Sujuan, Apostolova, Liana G.
Format: Article
Language:English
Subjects:
Age Factors
Age of Onset
Aged
Aged, 80 and over
Alzheimer Disease
behavioral and psychological symptoms in dementia
Cross-Sectional Studies
early‐onset Alzheimer's disease
Female
Humans
late‐onset Alzheimer's disease
Male
Middle Aged
neuropsychiatric symptoms
Neuropsychological Tests - statistics & numerical data
Severity of Illness Index
Symptom Burden
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Summary:INTRODUCTION We examined the burden of neuropsychiatric symptoms (NPSs) in early‐onset (EO) and late‐onset (LO) Alzheimer's disease (AD) and adjusted for age effects via the inclusion of cognitively unimpaired (CU) individuals. METHODS Cross‐sectional data from 2940 EOAD, 8665 LOAD, and 8775 age‐stratified CU individuals (early‐CU, n = 2433; late‐CU, n = 6342) from the National Alzheimer's Coordinating Center database were included. Fisher's exact tests compared EOAD and LOAD on the presence and severity of NPSs. Multiple logistic regression models included an age*diagnosis interaction to examine age effects. RESULTS Presence (ps 
ISSN:1552-5260
1552-5279
1552-5279
DOI:10.1002/alz.14042