Implication of Capillary Morphogenesis Gene 2 (CMG2) in the Disease Progression and Peritoneal Metastasis of Pancreatic Cancer

Capillary morphogenesis gene 2 (CMG2) mediates cell-matrix interactions to facilitate cell adhesion and migration. CMG2 has been implicated in the disease progression of breast cancer, prostate cancer and gastric cancer. The present study aims to determine the role of CMG2 in the disease progression...

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Bibliographic Details
Published in:Cancers 2024-08, Vol.16 (16), p.2893
Main Authors: Fang, Ziqian, Bunston, Carly, Xu, Yali, Ruge, Fiona, Sui, Laijian, Liu, Ming, Al-Sarireh, Bilal, Griffiths, Paul, Murphy, Kate, Pugh, Matthew R, Hao, Chunyi, Jiang, Wen G, Ye, Lin
Format: Article
Language:English
Subjects:
Annealing
Anthrax
Antibiotics
Antibodies
Breast cancer
Cell adhesion
Cell migration
Cells
Development and progression
Epidermal growth factor receptors
Focal adhesion kinase
Gastric cancer
Gene expression
Genetic aspects
Genomes
Glioma
Hyaluronic acid
Laboratories
Medical prognosis
Metastases
Metastasis
Morphogenesis
Pancreatic cancer
Peritoneum
Prostate cancer
Proteins
Proteomics
Sarcoma
Survival analysis
Toxins
Tumors
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Summary:Capillary morphogenesis gene 2 (CMG2) mediates cell-matrix interactions to facilitate cell adhesion and migration. CMG2 has been implicated in the disease progression of breast cancer, prostate cancer and gastric cancer. The present study aims to determine the role of CMG2 in the disease progression and peritoneal metastasis of pancreatic cancer. Pancreatic tumour samples were collected from Peking University Cancer Hospital. CMG2 expression was determined using quantitative PCR. After the creation of knockdown and overexpression of CMG2 in pancreatic cancer cells, the effect of CMG2 on several cell functions and adhesion to the peritoneum was examined. Potential pathways regulated by CMG2 were found via proteomics analysis and drug tests. CMG2 was upregulated in pancreatic cancer tissues and associated with a poor prognosis. CMG2 was increased in metastatic lesions and those primary tumours with distant metastases. CMG2 promotes cell-cell, cell-matrix and cell-hyaluronic acid adhesion, which may be mediated by epidermal growth factor receptor (EGFR) and focal adhesion kinase (FAK) pathway activation.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers16162893