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Structural Variations Identified in Patients with Autism Spectrum Disorder (ASD) in the Chinese Population: A Systematic Review of Case-Control Studies

Autistic spectrum disorder (ASD) is a neurodevelopmental disability characterised by the impairment of social interaction and communication ability. The alarming increase in its prevalence in children urged researchers to obtain a better understanding of the causes of this disease. Genetic factors a...

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Published in:	Genes 2024-08, Vol.15 (8), p.1082
Main Authors:	Chair, Sek-Ying, Chow, Ka-Ming, Chan, Cecilia Wai-Ling, Chan, Judy Yuet-Wa, Law, Bernard Man-Hin, Waye, Mary Miu-Yee
Format:	Article
Language:	English
Subjects:	Asian People - genetics Autism Autism Spectrum Disorder - epidemiology Autism Spectrum Disorder - genetics Case-Control Studies Child China China - epidemiology Chinese East Asian People etiology Genes Genetic aspects Genetic factors Genetic Predisposition to Disease Genetic screening Humans Identification and classification Mental disorders Minority & ethnic groups nationalities and ethnic groups Neurodevelopmental disorders Physiological aspects Population genetics Population studies social behavior Systematic Review White people
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description	Autistic spectrum disorder (ASD) is a neurodevelopmental disability characterised by the impairment of social interaction and communication ability. The alarming increase in its prevalence in children urged researchers to obtain a better understanding of the causes of this disease. Genetic factors are considered to be crucial, as ASD has a tendency to run in families. In recent years, with technological advances, the importance of structural variations (SVs) in ASD began to emerge. Most of these studies, however, focus on the Caucasian population. As a populated ethnicity, ASD shall be a significant health issue in China. This systematic review aims to summarise current case-control studies of SVs associated with ASD in the Chinese population. A list of genes identified in the nine included studies is provided. It also reveals that similar research focusing on other genetic backgrounds is demanded to manifest the disease etiology in different ethnic groups, and assist the development of accurate ethnic-oriented genetic diagnosis.
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subjects	Asian People - genetics Autism Autism Spectrum Disorder - epidemiology Autism Spectrum Disorder - genetics Case-Control Studies Child China China - epidemiology Chinese East Asian People etiology Genes Genetic aspects Genetic factors Genetic Predisposition to Disease Genetic screening Humans Identification and classification Mental disorders Minority & ethnic groups nationalities and ethnic groups Neurodevelopmental disorders Physiological aspects Population genetics Population studies social behavior Systematic Review White people
title	Structural Variations Identified in Patients with Autism Spectrum Disorder (ASD) in the Chinese Population: A Systematic Review of Case-Control Studies
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