The Effect of Ascorbic Acid on Hepatic Ischaemia-Reperfusion Injury in Wistar Rats: An Experimental Study

Liver ischaemia-reperfusion (IR) during hepatic surgeries can lead to liver cell death via oxidative stress and the activation of immune cells, the release of cytokines, and damage-associated molecular patterns. Ascorbic acid has been shown to confer potential protective effects against IR injury, m...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-08, Vol.25 (16), p.8833
Main Authors: Ximenes, Jorge Luiz Saraiva, Rocha-Filho, Joel Avancini, Galvão, Flavio Henrique Ferreira, Lanchotte, Cinthia, Kubrusly, Marcia Saldanha, Leitão, Regina Maria Cubero, Jukemura, Jose, Moscoso, Agustin Vintimilla, Abdo, Emilio Elias, D'Albuquerque, Luiz Augusto Carneiro, Figueira, Estela Regina Ramos
Format: Article
Language:English
Subjects:
Acids
Animals
Antioxidants - pharmacology
Ascorbic Acid - pharmacology
Cytokines
Cytokines - metabolism
Disease Models, Animal
Injuries
Ischemia
Liver
Liver - drug effects
Liver - metabolism
Liver - pathology
Male
Oxidative Stress - drug effects
Portal Vein
Rats
Rats, Wistar
Reperfusion Injury - drug therapy
Reperfusion Injury - metabolism
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Summary:Liver ischaemia-reperfusion (IR) during hepatic surgeries can lead to liver cell death via oxidative stress and the activation of immune cells, the release of cytokines, and damage-associated molecular patterns. Ascorbic acid has been shown to confer potential protective effects against IR injury, mainly due to its antioxidant properties. This study evaluated the effect of ascorbic acid infusion at different time points during hepatic IR in rats. Thirty-six male Wistar rats were divided into control and experimental groups that received the same total ascorbic acid dose at three different infusion times: before ischaemia, before reperfusion, or before both ischaemia and reperfusion. All of the animals experienced hepatic IR injury. We measured the hepatic enzymes, cytokines, and portal blood flow. Animals receiving ascorbic acid before both ischaemia and reperfusion had lower liver enzyme levels, reduced inflammation, and better portal venous flow than other animals. Divided doses of ascorbic acid before IR may be beneficial for reducing liver injury associated with IR.
ISSN:1661-6596
1422-0067
1422-0067
DOI:10.3390/ijms25168833