Dietary Isoflavones Intake and Gastric Cancer

Dietary isoflavones have been associated with a lower risk of gastric cancer (GC), but the evidence for this association is still limited. We investigated the association between isoflavone intake and GC risk using data from a case-control study including 230 incident, histologically confirmed GC ca...

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Bibliographic Details
Published in:Nutrients 2024-08, Vol.16 (16), p.2771
Main Authors: Natale, Arianna, Fiori, Federica, Parpinel, Maria, Pelucchi, Claudio, Negri, Eva, La Vecchia, Carlo, Rossi, Marta
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Apoptosis
Bioavailability
Case-Control Studies
daidzein
Diet - statistics & numerical data
Education
energy intake
Family medical history
Female
Females
Flavonoids
Food
food frequency questionnaires
Gastric cancer
genistein
Genistein - administration & dosage
Humans
Isoflavones - administration & dosage
Legumes
Logistic Models
Male
Microbiota
Middle Aged
Nutrition research
Odds Ratio
Questionnaires
regression analysis
risk
Risk Factors
Smoking
stomach neoplasms
Stomach Neoplasms - epidemiology
Stomach Neoplasms - prevention & control
Tobacco
Trends
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Summary:Dietary isoflavones have been associated with a lower risk of gastric cancer (GC), but the evidence for this association is still limited. We investigated the association between isoflavone intake and GC risk using data from a case-control study including 230 incident, histologically confirmed GC cases and 547 controls with acute, non-neoplastic conditions. Dietary information was collected through a validated food frequency questionnaire (FFQ) and isoflavone intake was estimated using ad hoc databases. We estimated the odds ratios (OR) and the corresponding 95% confidence intervals (CI) of GC using logistic regression models, including terms for total energy intake and other major confounders. The OR for the highest versus the lowest tertile of intake was 0.65 (95%CI = 0.44-0.97, for trend = 0.04) for daidzein, 0.75 (95%CI = 0.54-1.11, for trend = 0.15) for genistein, and 0.66 (95%CI = 0.45-0.99, for trend = 0.05) for total isoflavones. Stratified analyses by sex, age, education, and smoking showed no heterogeneity. These findings indicate a favorable effect of dietary isoflavones on GC.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu16162771