Putative capacitative calcium entry channels: expression of Drosophila trp and evidence for the existence of vertebrate homologues

Capacitative calcium entry is a major pathway through which intracellular calcium stores are refilled after stimulation. It has been suggested that the protein encoded by the transient receptor potential (trp) gene expressed in Drosophila photoreceptors may be homologous with capacitative calcium en...

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Bibliographic Details
Published in:Biochemical journal 1995-10, Vol.311 ( Pt 1) (1), p.41-44
Main Authors: Petersen, C C, Berridge, M J, Borgese, M F, Bennett, D L
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Brain - metabolism
Calcium - metabolism
Calcium Channels - genetics
Calcium Channels - physiology
Calmodulin-Binding Proteins - genetics
Calmodulin-Binding Proteins - physiology
Diptera - genetics
Drosophila
Drosophila Proteins
Female
Gene Expression
Insect Hormones - genetics
Insect Hormones - physiology
Insect Proteins
Ion Channel Gating
Membrane Proteins - genetics
Membrane Proteins - physiology
Mice
Molecular Sequence Data
Oocytes - metabolism
Polymerase Chain Reaction
Sequence Homology
Transient Receptor Potential Channels
Xenopus - genetics
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Summary:Capacitative calcium entry is a major pathway through which intracellular calcium stores are refilled after stimulation. It has been suggested that the protein encoded by the transient receptor potential (trp) gene expressed in Drosophila photoreceptors may be homologous with capacitative calcium entry channels. Expression of the trp gene product in Xenopus oocytes led to significant increases in calcium entry only when the intracellular calcium stores were depleted. Previous investigations have found trp to be uniquely expressed in Drosophila photoreceptors, but PCR cloning shows that homologous proteins exist in Calliphora, mouse brain and Xenopus oocytes. It is thus possible that capacitative calcium entry in Xenopus oocytes is mediated by a homologue of trp.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj3110041