Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: evidence for linkage with GSTM1A

Allelism in the glutathione S-transferase, GSTM3 gene has been identified using PCR with specific primers to exon 6/exon 7. Sequencing showed the mutant GSTM3*B allele to have a three-base deletion in intron 6 with a frequency of 0.158. The mutation generates a recognition sequence, 5'-AAGATA-3...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical journal 1995-12, Vol.312 ( Pt 3) (Pt 3), p.713-716
Main Authors: Inskip, A, Elexperu-Camiruaga, J, Buxton, N, Dias, P S, MacIntosh, J, Campbell, D, Jones, P W, Yengi, L, Talbot, J A, Strange, R C
Format: Article
Language:English
Subjects:
Base Sequence
Binding Sites
DNA-Binding Proteins - metabolism
Erythroid-Specific DNA-Binding Factors
Exons
Gene Deletion
Gene Frequency
Genetic Linkage
Glutathione Transferase - genetics
Humans
Introns
Molecular Sequence Data
Neoplasms - genetics
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Transcription Factors - metabolism
YY1 Transcription Factor
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Allelism in the glutathione S-transferase, GSTM3 gene has been identified using PCR with specific primers to exon 6/exon 7. Sequencing showed the mutant GSTM3*B allele to have a three-base deletion in intron 6 with a frequency of 0.158. The mutation generates a recognition sequence, 5'-AAGATA-3', for the negative transcription factor YY1. GSTM3*B was significantly associated with GSTM1*A.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj3120713