DNA ploidy and PTEN as biomarkers for predicting aggressive disease in prostate cancer patients under active surveillance

Background Current risk stratification tools for prostate cancer patients under active surveillance (AS) may inadequately identify those needing treatment. We investigated DNA ploidy and PTEN as potential biomarkers to predict aggressive disease in AS patients. Methods We assessed DNA ploidy by imag...

Full description

Saved in:
Bibliographic Details
Published in:British journal of cancer 2024-09, Vol.131 (5), p.895-904
Main Authors: Cyll, Karolina, Skaaheim Haug, Erik, Pradhan, Manohar, Vlatkovic, Ljiljana, Carlsen, Birgitte, Löffeler, Sven, Kildal, Wanja, Skogstad, Karin, Hauge Torkelsen, Frida, Syvertsen, Rolf Anders, Askautrud, Hanne A., Liestøl, Knut, Kleppe, Andreas, Danielsen, Håvard E.
Format: Article
Language:English
Subjects:
631/208/211
631/67/1857
631/67/2329
692/4028/67/1244
692/4028/67/589/466
Aged
Biomarkers
Biomarkers, Tumor - genetics
Biomedical and Life Sciences
Biomedicine
Cancer Research
Deoxyribonucleic acid
DNA
DNA, Neoplasm - genetics
Drug Resistance
Epidemiology
Humans
Immunohistochemistry
Male
Middle Aged
Molecular Medicine
Oncology
Patients
Ploidies
Ploidy
Prognosis
Prostate cancer
Prostatic Neoplasms - genetics
Prostatic Neoplasms - pathology
PTEN Phosphohydrolase - genetics
PTEN protein
Risk assessment
Surveillance
Tumors
Watchful Waiting
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Current risk stratification tools for prostate cancer patients under active surveillance (AS) may inadequately identify those needing treatment. We investigated DNA ploidy and PTEN as potential biomarkers to predict aggressive disease in AS patients. Methods We assessed DNA ploidy by image cytometry and PTEN protein expression by immunohistochemistry in 3197 tumour-containing tissue blocks from 558 patients followed in AS at a Norwegian local hospital. The primary endpoint was treatment, with treatment failure (biochemical recurrence or initiation of salvage therapy) as the secondary endpoint. Results The combined DNA ploidy and PTEN (DPP) status at diagnosis was associated with treatment-free survival in univariable- and multivariable analysis, with a HR for DPP-aberrant vs. DPP-normal tumours of 2.12 ( p  
ISSN:0007-0920
1532-1827
1532-1827
DOI:10.1038/s41416-024-02780-x