Oestradiol-induced changes in the composition of phospholipid classes of quail oviduct : specific replacement of arachidonic acid by docosahexaenoic acid in alkenylacyl-glycerophosphoethanolamine

The phospholipid composition and the molecular species of the major subclasses of ethanolamine and choline glycerophospholipids were determined during the natural or oestradiol-induced development of the quail oviduct. The phospholipid concentration increased significantly during oviduct development...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical journal 1994-07, Vol.301 (2), p.361-366
Main Authors: FELOUATI, B.-E, PAGEAUX, J.-F, FAYARD, J.-M, LAGARDE, M, LAUGIER, C
Format: Article
Language:English
Subjects:
Animals
Arachidonic Acid - metabolism
Biological and medical sciences
Coturnix - metabolism
Docosahexaenoic Acids - metabolism
Estradiol - pharmacology
Female
Fundamental and applied biological sciences. Psychology
Non mammalian vertebrate reproduction
Oviducts - drug effects
Oviducts - growth & development
Oviducts - metabolism
Phosphatidylcholines - metabolism
Phosphatidylethanolamines - metabolism
Phospholipids - metabolism
Sexual Maturation
Vertebrates: reproduction
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The phospholipid composition and the molecular species of the major subclasses of ethanolamine and choline glycerophospholipids were determined during the natural or oestradiol-induced development of the quail oviduct. The phospholipid concentration increased significantly during oviduct development, and the proportion of ethanolamine glycerophospholipids (EPL) remained constant while that of choline glycerophospholipids increased. The immature oviduct contained the majority of its endogenous arachidonic acid mass (71%) in EPL, mainly in alkenylacyl-glycerophosphoethanolamine (alkenylacyl-GPE) (49% of the total). Oestrogen treatment induced the depletion of 20:4,n-6 specifically from this pool, which indicates the biological importance of 20:4,n-6 molecular species in alkenylacyl-GPE as substrates for the oviduct phospholipases activated by oestradiol, and suggests that this EPL subclass is involved in the oestrogen-induced cell proliferation. Another striking result was the marked increase in 22:6,n-3 EPL molecular species following the oestradiol treatment and more particularly the strict substitution of 20:4,n-6 by 22:6,n-3 in alkenylacyl-GPE. We speculate that alkenylacyl-GPE molecular species containing 22:6,n-3 may participate in the arrest of oestrogen-induced proliferation.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj3010361