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Oestradiol-induced changes in the composition of phospholipid classes of quail oviduct : specific replacement of arachidonic acid by docosahexaenoic acid in alkenylacyl-glycerophosphoethanolamine
The phospholipid composition and the molecular species of the major subclasses of ethanolamine and choline glycerophospholipids were determined during the natural or oestradiol-induced development of the quail oviduct. The phospholipid concentration increased significantly during oviduct development...
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Published in: | Biochemical journal 1994-07, Vol.301 (2), p.361-366 |
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creator | FELOUATI, B.-E PAGEAUX, J.-F FAYARD, J.-M LAGARDE, M LAUGIER, C |
description | The phospholipid composition and the molecular species of the major subclasses of ethanolamine and choline glycerophospholipids were determined during the natural or oestradiol-induced development of the quail oviduct. The phospholipid concentration increased significantly during oviduct development, and the proportion of ethanolamine glycerophospholipids (EPL) remained constant while that of choline glycerophospholipids increased. The immature oviduct contained the majority of its endogenous arachidonic acid mass (71%) in EPL, mainly in alkenylacyl-glycerophosphoethanolamine (alkenylacyl-GPE) (49% of the total). Oestrogen treatment induced the depletion of 20:4,n-6 specifically from this pool, which indicates the biological importance of 20:4,n-6 molecular species in alkenylacyl-GPE as substrates for the oviduct phospholipases activated by oestradiol, and suggests that this EPL subclass is involved in the oestrogen-induced cell proliferation. Another striking result was the marked increase in 22:6,n-3 EPL molecular species following the oestradiol treatment and more particularly the strict substitution of 20:4,n-6 by 22:6,n-3 in alkenylacyl-GPE. We speculate that alkenylacyl-GPE molecular species containing 22:6,n-3 may participate in the arrest of oestrogen-induced proliferation. |
doi_str_mv | 10.1042/bj3010361 |
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The phospholipid concentration increased significantly during oviduct development, and the proportion of ethanolamine glycerophospholipids (EPL) remained constant while that of choline glycerophospholipids increased. The immature oviduct contained the majority of its endogenous arachidonic acid mass (71%) in EPL, mainly in alkenylacyl-glycerophosphoethanolamine (alkenylacyl-GPE) (49% of the total). Oestrogen treatment induced the depletion of 20:4,n-6 specifically from this pool, which indicates the biological importance of 20:4,n-6 molecular species in alkenylacyl-GPE as substrates for the oviduct phospholipases activated by oestradiol, and suggests that this EPL subclass is involved in the oestrogen-induced cell proliferation. Another striking result was the marked increase in 22:6,n-3 EPL molecular species following the oestradiol treatment and more particularly the strict substitution of 20:4,n-6 by 22:6,n-3 in alkenylacyl-GPE. We speculate that alkenylacyl-GPE molecular species containing 22:6,n-3 may participate in the arrest of oestrogen-induced proliferation.</description><identifier>ISSN: 0264-6021</identifier><identifier>EISSN: 1470-8728</identifier><identifier>DOI: 10.1042/bj3010361</identifier><identifier>PMID: 8042978</identifier><language>eng</language><publisher>Colchester: Portland Press</publisher><subject>Animals ; Arachidonic Acid - metabolism ; Biological and medical sciences ; Coturnix - metabolism ; Docosahexaenoic Acids - metabolism ; Estradiol - pharmacology ; Female ; Fundamental and applied biological sciences. Psychology ; Non mammalian vertebrate reproduction ; Oviducts - drug effects ; Oviducts - growth & development ; Oviducts - metabolism ; Phosphatidylcholines - metabolism ; Phosphatidylethanolamines - metabolism ; Phospholipids - metabolism ; Sexual Maturation ; Vertebrates: reproduction</subject><ispartof>Biochemical journal, 1994-07, Vol.301 (2), p.361-366</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3801-b1a6547c5648188da36824c80bdcc2ac30d2a6786e815adf2dfd962b28f032423</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1137088/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1137088/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4180053$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8042978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>FELOUATI, B.-E</creatorcontrib><creatorcontrib>PAGEAUX, J.-F</creatorcontrib><creatorcontrib>FAYARD, J.-M</creatorcontrib><creatorcontrib>LAGARDE, M</creatorcontrib><creatorcontrib>LAUGIER, C</creatorcontrib><title>Oestradiol-induced changes in the composition of phospholipid classes of quail oviduct : specific replacement of arachidonic acid by docosahexaenoic acid in alkenylacyl-glycerophosphoethanolamine</title><title>Biochemical journal</title><addtitle>Biochem J</addtitle><description>The phospholipid composition and the molecular species of the major subclasses of ethanolamine and choline glycerophospholipids were determined during the natural or oestradiol-induced development of the quail oviduct. The phospholipid concentration increased significantly during oviduct development, and the proportion of ethanolamine glycerophospholipids (EPL) remained constant while that of choline glycerophospholipids increased. The immature oviduct contained the majority of its endogenous arachidonic acid mass (71%) in EPL, mainly in alkenylacyl-glycerophosphoethanolamine (alkenylacyl-GPE) (49% of the total). Oestrogen treatment induced the depletion of 20:4,n-6 specifically from this pool, which indicates the biological importance of 20:4,n-6 molecular species in alkenylacyl-GPE as substrates for the oviduct phospholipases activated by oestradiol, and suggests that this EPL subclass is involved in the oestrogen-induced cell proliferation. Another striking result was the marked increase in 22:6,n-3 EPL molecular species following the oestradiol treatment and more particularly the strict substitution of 20:4,n-6 by 22:6,n-3 in alkenylacyl-GPE. We speculate that alkenylacyl-GPE molecular species containing 22:6,n-3 may participate in the arrest of oestrogen-induced proliferation.</description><subject>Animals</subject><subject>Arachidonic Acid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Coturnix - metabolism</subject><subject>Docosahexaenoic Acids - metabolism</subject><subject>Estradiol - pharmacology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Non mammalian vertebrate reproduction</subject><subject>Oviducts - drug effects</subject><subject>Oviducts - growth & development</subject><subject>Oviducts - metabolism</subject><subject>Phosphatidylcholines - metabolism</subject><subject>Phosphatidylethanolamines - metabolism</subject><subject>Phospholipids - metabolism</subject><subject>Sexual Maturation</subject><subject>Vertebrates: reproduction</subject><issn>0264-6021</issn><issn>1470-8728</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><recordid>eNpVkc1u1TAQhS0EKreFBQ-A5AVC6iJgO76Oy6ISqviTKnUD62gydm5cHDu1k4o8Hy-Gq4YrWFiW5nxzzthDyCvO3nEmxfvutmac1Yo_ITsuG1bpRuinZMeEkpVigj8npznfMsYlk-yEnOjSddHoHfl9Y_OcwLjoKxfMgtZQHCAcbKYu0HmwFOM4xexmFwONPZ2GmMvxbnIF9ZBzQUv9bgHnabx3xWSmH2ieLLreIU128oB2tGF-4CABDs7EUCTA4tGt1ESMGQb7C2yIf-slHvxPG9bSvfrq4Fe0KW7xdi5DRg-jC_YFedaDz_bldp-RH58_fb_6Wl3ffPl29fG6wlozXnUc1F42uFdSc60N1EoLiZp1BlEA1swIUI1WVvM9mF6Y3lwo0Qnds1pIUZ-Ry0ffaelGa7A8KIFvp-RGSGsbwbX_K8EN7SHet5zXDdO6GLzdDFK8W8rHt6PLaL2HYOOS20YproWWBTx_BDHFnJPtjyGctQ8bb48bL-zrf6c6ktuKi_5m0yEj-D5BQJePmOSasX1d_wF9xrni</recordid><startdate>19940715</startdate><enddate>19940715</enddate><creator>FELOUATI, B.-E</creator><creator>PAGEAUX, J.-F</creator><creator>FAYARD, J.-M</creator><creator>LAGARDE, M</creator><creator>LAUGIER, C</creator><general>Portland Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19940715</creationdate><title>Oestradiol-induced changes in the composition of phospholipid classes of quail oviduct : specific replacement of arachidonic acid by docosahexaenoic acid in alkenylacyl-glycerophosphoethanolamine</title><author>FELOUATI, B.-E ; PAGEAUX, J.-F ; FAYARD, J.-M ; LAGARDE, M ; LAUGIER, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3801-b1a6547c5648188da36824c80bdcc2ac30d2a6786e815adf2dfd962b28f032423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Arachidonic Acid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Coturnix - metabolism</topic><topic>Docosahexaenoic Acids - metabolism</topic><topic>Estradiol - pharmacology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Non mammalian vertebrate reproduction</topic><topic>Oviducts - drug effects</topic><topic>Oviducts - growth & development</topic><topic>Oviducts - metabolism</topic><topic>Phosphatidylcholines - metabolism</topic><topic>Phosphatidylethanolamines - metabolism</topic><topic>Phospholipids - metabolism</topic><topic>Sexual Maturation</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FELOUATI, B.-E</creatorcontrib><creatorcontrib>PAGEAUX, J.-F</creatorcontrib><creatorcontrib>FAYARD, J.-M</creatorcontrib><creatorcontrib>LAGARDE, M</creatorcontrib><creatorcontrib>LAUGIER, C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biochemical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FELOUATI, B.-E</au><au>PAGEAUX, J.-F</au><au>FAYARD, J.-M</au><au>LAGARDE, M</au><au>LAUGIER, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oestradiol-induced changes in the composition of phospholipid classes of quail oviduct : specific replacement of arachidonic acid by docosahexaenoic acid in alkenylacyl-glycerophosphoethanolamine</atitle><jtitle>Biochemical journal</jtitle><addtitle>Biochem J</addtitle><date>1994-07-15</date><risdate>1994</risdate><volume>301</volume><issue>2</issue><spage>361</spage><epage>366</epage><pages>361-366</pages><issn>0264-6021</issn><eissn>1470-8728</eissn><abstract>The phospholipid composition and the molecular species of the major subclasses of ethanolamine and choline glycerophospholipids were determined during the natural or oestradiol-induced development of the quail oviduct. The phospholipid concentration increased significantly during oviduct development, and the proportion of ethanolamine glycerophospholipids (EPL) remained constant while that of choline glycerophospholipids increased. The immature oviduct contained the majority of its endogenous arachidonic acid mass (71%) in EPL, mainly in alkenylacyl-glycerophosphoethanolamine (alkenylacyl-GPE) (49% of the total). Oestrogen treatment induced the depletion of 20:4,n-6 specifically from this pool, which indicates the biological importance of 20:4,n-6 molecular species in alkenylacyl-GPE as substrates for the oviduct phospholipases activated by oestradiol, and suggests that this EPL subclass is involved in the oestrogen-induced cell proliferation. Another striking result was the marked increase in 22:6,n-3 EPL molecular species following the oestradiol treatment and more particularly the strict substitution of 20:4,n-6 by 22:6,n-3 in alkenylacyl-GPE. We speculate that alkenylacyl-GPE molecular species containing 22:6,n-3 may participate in the arrest of oestrogen-induced proliferation.</abstract><cop>Colchester</cop><pub>Portland Press</pub><pmid>8042978</pmid><doi>10.1042/bj3010361</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Arachidonic Acid - metabolism Biological and medical sciences Coturnix - metabolism Docosahexaenoic Acids - metabolism Estradiol - pharmacology Female Fundamental and applied biological sciences. Psychology Non mammalian vertebrate reproduction Oviducts - drug effects Oviducts - growth & development Oviducts - metabolism Phosphatidylcholines - metabolism Phosphatidylethanolamines - metabolism Phospholipids - metabolism Sexual Maturation Vertebrates: reproduction |
title | Oestradiol-induced changes in the composition of phospholipid classes of quail oviduct : specific replacement of arachidonic acid by docosahexaenoic acid in alkenylacyl-glycerophosphoethanolamine |
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