Spectrum of [18F]FDG PET/CT Findings in Primary Central Nervous System Lymphoma - A Pictorial Essay

Primary central nervous system lymphoma (PCNSL) is a rare, aggressive variant of extranodal non-Hodgkin's lymphoma. Although gadolinium-enhanced magnetic resonance imaging remains the initial imaging modality of choice, a whole-body F-18 fluorodeoxyglucose (FDG) positron emission tomography-com...

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Bibliographic Details
Published in:Indian journal of nuclear medicine 2024-05, Vol.39 (3), p.191-197
Main Authors: Nithya, V, Valaiyapathy, N C, Hemalatha, Dhamarcherla S, Ramya Priya, Rallapeta, Bhargavi, D, Kalawat, Tekchand
Format: Article
Language:English
Subjects:
Central nervous system
Computed tomography
Fluorine isotopes
Gadolinium
Lesions
Magnetic resonance imaging
Medical imaging
Pictorial
Positron emission
Radioisotopes
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Summary:Primary central nervous system lymphoma (PCNSL) is a rare, aggressive variant of extranodal non-Hodgkin's lymphoma. Although gadolinium-enhanced magnetic resonance imaging remains the initial imaging modality of choice, a whole-body F-18 fluorodeoxyglucose (FDG) positron emission tomography-computed tomography is imperative to exclude systemic lymphomatous involvement. Furthermore, the metabolic parameter, maximum standardized uptake value (SUV ) of the lesion, tumor-to-normal cerebral tissue SUV ratio, and FDG uptake patterns help in differentiating intracranial lymphomas from High-grade Glioblastoma Multiforme (HGM) and infectious lesions, and hence, consolidating the diagnosis. In this pictorial essay, we present a series of PCNSL cases, representing the different imaging characteristics and metabolic uptake patterns.
ISSN:0972-3919
0974-0244
DOI:10.4103/ijnm.ijnm_21_24