Laboratory investigation of monoclonal gammopathy during 10 years of screening in a general hospital

Protein electrophoresis was carried out on 102,000 samples from the patients of a district general hospital over 10 years, and a monoclonal protein was detected in 730 cases; of these, 114 could be classified as B cell malignancies and 261 as monoclonal gammopathy of undefined significance (MGUS). T...

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Bibliographic Details
Published in:Journal of clinical pathology 1987-07, Vol.40 (7), p.793-797
Main Authors: Malacrida, V, De Francesco, D, Banfi, G, Porta, F A, Riches, P G
Format: Article
Language:English
Subjects:
Age Factors
Aged
B-Lymphocytes
Bence Jones Protein - urine
Biological and medical sciences
Blood Protein Electrophoresis
Female
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunoglobulin Heavy Chains - analysis
Immunoglobulin Light Chains - analysis
Immunoglobulinopathies
Immunopathology
Male
Medical sciences
Middle Aged
Multiple Myeloma - blood
Paraproteinemias - blood
Time Factors
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Summary:Protein electrophoresis was carried out on 102,000 samples from the patients of a district general hospital over 10 years, and a monoclonal protein was detected in 730 cases; of these, 114 could be classified as B cell malignancies and 261 as monoclonal gammopathy of undefined significance (MGUS). The various clinical and laboratory features of monoclonal gammopathy were examined with respect to distinguishing the malignant conditions from MGUS at first presentation.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.40.7.793