Czech Footprints in the Bioenergetics Research

Life manifests as growth, movement or heat production that occurs thanks to the energy accepted from the outside environment. The basis of energy transduction attracted the Czech researchers since the beginning of the 20th century. It further accelerated after World War II, when the new Institute of...

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Bibliographic Details
Published in:Physiological research 2024-05, Vol.73 (Suppl 1), p.S23-S33
Main Authors: Drahota, Zdeněk, Houštěk, Josef, Pecinová, Alena
Format: Article
Language:English
Subjects:
Adenosine triphosphate
ATP
Biochemistry
Bioenergetics
Body fat
Collaboration
Energy
Energy transduction
Krebs, Hans
Laboratories
Metabolism
Metabolites
Mitochondria
Oxidation
Oxidative phosphorylation
Phosphorylation
Physiology
Protons
Respiration
Review
Students
Warburg, Otto
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Summary:Life manifests as growth, movement or heat production that occurs thanks to the energy accepted from the outside environment. The basis of energy transduction attracted the Czech researchers since the beginning of the 20th century. It further accelerated after World War II, when the new Institute of Physiology was established in 1954. When it was found that energy is stored in the form of adenosine triphosphate (ATP) that can be used by numerous reactions as energy source and is produced in the process called oxidative phosphorylation localized in mitochondria, the investigation focused on this cellular organelle. Although the Czech scientists had to overcome various obstacles including Communist party leadership, driven by curiosity, boldness, and enthusiasm, they characterized broad spectrum of mitochondrial properties in different tissues in (patho)physiological conditions in collaboration with many world-known laboratories. The current review summarizes the contribution of the Czech scientists to the bioenergetic and mitochondrial research in the global context.
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.935395