Rapid complete blood count and C-reactive protein determination with the Horiba Microsemi analyzer: the experience in neonatal intensive care unit of Careggi University Hospital

Microsystems represent an alternative but proficient approach of analysis outside the laboratory, and their use could help in reducing the impact of pre-analytical errors, in particular in challenging newborn samples. The study purpose is to compare the Horiba Microsemi CRP LC-767G system for rapid...

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Bibliographic Details
Published in:European journal of pediatrics 2024-10, Vol.183 (10), p.4477-4490
Main Authors: Nencini, Francesca, Bonari, Alessandro, Romano, Francesca, Ciullini Mannurita, Sara, Mongia, Alessandra, Garieri, Maria, Dani, Carlo, Manzo, Orazio, Pontieri, Maria, Fanelli, Alessandra
Format: Article
Language:English
Subjects:
Adult
Blood Cell Count - instrumentation
Blood Cell Count - methods
Blood Cell Count - statistics & numerical data
Blood tests
C-reactive protein
C-Reactive Protein - analysis
Female
Hospitals, University
Humans
Infant, Newborn
Intensive care
Intensive Care Units, Neonatal
Laboratories
Lymphocytes
Male
Medicine
Medicine & Public Health
Middle Aged
Monocytes
Neonates
Patients
Pediatrics
Regression analysis
Reproducibility of Results
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Summary:Microsystems represent an alternative but proficient approach of analysis outside the laboratory, and their use could help in reducing the impact of pre-analytical errors, in particular in challenging newborn samples. The study purpose is to compare the Horiba Microsemi CRP LC-767G system for rapid 3-part complete blood count (CBC) and C-reactive protein (CRP) determination with the laboratory reference systems (respectively Sysmex XN-9100™ and Roche Cobas® c702) in samples of adult patients and newborns hospitalized in the neonatal intensive care unit (NICU) samples. The comparison between the analyzers was performed through Passing-Bablok regression analysis and Bland–Altman plot. One hundred eighty-three blood samples were analyzed. The regression analysis results, performed in the newborn ( n  = 70) and in adult ( n  = 113) populations, showed a good agreement between the instruments. The evaluation of the Bland–Altman plots showed comparable values of bias 
ISSN:1432-1076
0340-6199
1432-1076
DOI:10.1007/s00431-024-05695-0