Tuberculous lymphadenitis associated with human immunodeficiency virus (HIV) in Uganda

Sixteen adults presented with lymphadenopathy which was tuberculous on biopsy; they were all seropositive for human immunodeficiency virus (HIV-1), but none had the clinical criteria of the acquired immunodeficiency syndrome (AIDS). The biopsy specimen showed caseating tuberculosis, with scanty or n...

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Bibliographic Details
Published in:Journal of clinical pathology 1988-01, Vol.41 (1), p.93-96
Main Authors: Nambuya, A, Sewankambo, N, Mugerwa, J, Goodgame, R, Lucas, S
Format: Article
Language:English
Subjects:
Adolescent
Adult
AIDS/HIV
Bacterial diseases
Biological and medical sciences
Female
HIV Seropositivity - complications
HIV Seropositivity - pathology
Human bacterial diseases
human immunodeficiency virus
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Lymph Nodes - pathology
Male
Medical sciences
Mycobacterium tuberculosis
Population
Tropical medicine
Tuberculosis and atypical mycobacterial infections
Tuberculosis, Lymph Node - complications
Tuberculosis, Lymph Node - pathology
Uganda
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Sixteen adults presented with lymphadenopathy which was tuberculous on biopsy; they were all seropositive for human immunodeficiency virus (HIV-1), but none had the clinical criteria of the acquired immunodeficiency syndrome (AIDS). The biopsy specimen showed caseating tuberculosis, with scanty or no visible acid fast bacilli in seven cases; the remaining nine had a poor cellular reactivity with numerous bacilli. Antituberculous chemotherapy for two months reduced the lymphadenopathy. Two patients subsequently developed AIDS. Mycobacterial cultures were not performed, but the infection was almost certainly Mycobacterium tuberculosis. The space-time clustering of tuberculous lymphadenitis now seen in Kampala, and the unusual non-reactive histopathology, are typical of the impairment of cellular immunity induced by HIV infection.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.41.1.93