Crosstalk between bone and the immune system

Bone functions not only as a critical element of the musculoskeletal system but also serves as the primary lymphoid organ harboring hematopoietic stem cells (HSCs) and immune progenitor cells. The interdisciplinary field of osteoimmunology has illuminated the dynamic interactions between the skeleta...

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Bibliographic Details
Published in:Journal of bone and mineral metabolism 2024-07, Vol.42 (4), p.470-480
Main Author: Okamoto, Kazuo
Format: Article
Language:English
Subjects:
Autoimmune diseases
Bone marrow
Bone remodeling
Cell activation
Cell differentiation
Genetic crosses
Hematopoietic stem cells
Hemopoiesis
Homeostasis
Immune response
Immune system
Immunological diseases
Invited Review
Medicine
Medicine & Public Health
Metabolic Diseases
Microenvironments
Musculoskeletal system
Orthopedics
Osteoblastogenesis
Osteoclastogenesis
Osteoclasts
Osteoprogenitor cells
Pathogenesis
Progenitor cells
Rheumatoid arthritis
Tumorigenesis
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Description
Summary:Bone functions not only as a critical element of the musculoskeletal system but also serves as the primary lymphoid organ harboring hematopoietic stem cells (HSCs) and immune progenitor cells. The interdisciplinary field of osteoimmunology has illuminated the dynamic interactions between the skeletal and immune systems, vital for the maintenance of skeletal tissue homeostasis and the pathogenesis of immune and skeletal diseases. Aberrant immune activation stimulates bone cells such as osteoclasts and osteoblasts, disturbing the bone remodeling and leading to skeletal disorders as seen in autoimmune diseases like rheumatoid arthritis. On the other hand, intricate multicellular network within the bone marrow creates a specialized microenvironment essential for the maintenance and differentiation of HSCs and the progeny. Dysregulation of immune–bone crosstalk in the bone marrow environment can trigger tumorigenesis and exacerbated inflammation. A comprehensive deciphering of the complex “immune–bone crosstalk” leads to a deeper understanding of the pathogenesis of immune diseases as well as skeletal diseases, and might provide insight into potential therapeutic approaches.
ISSN:0914-8779
1435-5604
1435-5604
DOI:10.1007/s00774-024-01539-x