Effects of improved glycaemic control on calcium and magnesium homeostasis in type II diabetes

Poorly controlled type II diabetic patients with hypomagnesaemia, hypermagnesuria, and hypercalciuria were allocated to treatment with either metformin or glipizide, to determine the effects on some indices of mineral metabolism. Despite comparable improvement in glycaemic control, assessed by gluco...

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Bibliographic Details
Published in:Journal of clinical pathology 1988-09, Vol.41 (9), p.933-935
Main Authors: McBain, A M, Brown, I R, Menzies, D G, Campbell, I W
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Blood Glucose - metabolism
Calcium - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - drug therapy
Endocrinopathies
Female
Glipizide - therapeutic use
Homeostasis
Humans
Longitudinal Studies
Magnesium - blood
Male
Medical sciences
Metformin - therapeutic use
Middle Aged
Sulfonylurea Compounds - therapeutic use
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Summary:Poorly controlled type II diabetic patients with hypomagnesaemia, hypermagnesuria, and hypercalciuria were allocated to treatment with either metformin or glipizide, to determine the effects on some indices of mineral metabolism. Despite comparable improvement in glycaemic control, assessed by glucose and haemoglobin A1, there were significant differences between the two groups in the handling of magnesium. Patients receiving metformin showed a reduction in magnesium excretion but remained hypomagnesaemic and hypercalciuric. In contrast, patients receiving glipizide exhibited little change in either magnesium or calcium excretion but showed a significant rise in serum magnesium.
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.41.9.933