Comparative Evaluation of Salivary Cathelicidin and 8-Isoprostane Levels Among Smokeless Tobacco Users and Non-users and Their Correlation With Periodontal Health and Disease: A Cross-Sectional Study

Introduction Periodontal diseases arise from host-microbial interactions influenced by tobacco products. Salivary antimicrobial peptides such as salivary cathelicidin and prostaglandins such as 8-isoprostane are part of the inflammatory cascade affecting periodontal disease pathogenesis. Methodology...

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Published in:Curēus (Palo Alto, CA) CA), 2024-08, Vol.16 (8), p.e67646
Main Authors: Karambelkar, Mugdha V, Varma, Siddhartha, Suragimath, Girish, Zope, Sameer A, Mashalkar, Vaishali S, Kale, Apurva V
Format: Article
Language:English
Subjects:
Biomarkers
Cross-sectional studies
Dentistry
Enzymes
Gum disease
Homeostasis
Medical Education
Oral hygiene
Oral Medicine
Oxidative stress
Periodontium
Sample size
Statistical analysis
Tobacco
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Summary:Introduction Periodontal diseases arise from host-microbial interactions influenced by tobacco products. Salivary antimicrobial peptides such as salivary cathelicidin and prostaglandins such as 8-isoprostane are part of the inflammatory cascade affecting periodontal disease pathogenesis. Methodology A total of 93 patients, 31 in each group that is healthy, periodontitis, and periodontitis with smokeless tobacco habit patients, were enrolled. The case history was recorded, and clinical examination was performed using periodontal parameter analysis of oral hygiene index simplified (OHIS), Russell's index, periodontal pocket depth (PPD), and clinical attachment level (CAL). The saliva samples were collected and subjected to an enzyme-linked immunosorbent assay (ELISA) to evaluate cathelicidin and 8-isoprostane. The results were analysed and compared statistically. Results The OHIS, Russell's index, pocket probing depth, and CAL were high in patients with periodontitis and tobacco habit (p
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.67646