Influence of autonomic nervous dysfunction on eating during hemodialysis sessions: An observational study

• Published in: Medicine (Baltimore) 2024-09, Vol.103 (38), p.e39680
• Main Authors: Xiao, Dan, Li, Xia, Li, Yi, Mo, Liwen, Li, Xianglian, Fu, Yonggang, Zhang, Fan, Wang, Tao, Cheng, Yue, Li, Yunming, Zhou, Pengfei
• Format: Article
• Language: English
• Subjects: Adult; Aged; Autonomic Nervous System - physiopathology; Autonomic Nervous System Diseases - etiology; Autonomic Nervous System Diseases - physiopathology; Blood Glucose - analysis; Blood Pressure - physiology; Eating - physiology; Electrocardiography, Ambulatory; Female; Heart Rate - physiology; Humans; Male; Middle Aged; Observational Study; Prospective Studies; Renal Dialysis - adverse effects; Risk Factors
• ISSN: 0025-7974; 1536-5964; 1536-5964
• DOI: 10.1097/MD.0000000000039680

Although some studies have indicated that eating during hemodialysis may induce hypotension and cardiovascular events, some patients still consume food during their treatment. This prospective study was conducted to determine whether the need to eat during hemodialysis treatment was related to abnormal glucose metabolism and autonomic nerve dysfunction. Seventy patients were enrolled in this study, and their demographic features and various laboratory parameters were analyzed. At each routine hemodialysis visit, predialysis, intradialysis, and postdialysis blood pressure measurements were systematically conducted. A 24-hour ambulatory electrocardiogram (ECG) was performed during the hemodialysis interval, and heart rate variability (HRV) values were calculated. Additionally, whether the patients ate during the hemodialysis treatments was recorded. Another 20 people who underwent physical examinations during the same period and were matched for sex and age were included in the control group. The HRV values of the hemodialysis patients were generally lower than those of the control group. Univariate analysis revealed significant differences in sex, age, calcium antagonist use, blood calcium levels, insulin levels, diastolic blood pressure (DBP) measurements, and HRV indices between hemodialysis patients who ate and those who did not eat during hemodialysis (P  .05). Multivariate analysis revealed that low values for very low frequency (VLF) and postdialysis DBP were risk factors for fasting intolerance during hemodialysis treatments. Autonomic dysfunction may affect whether hemodialysis patients tolerate fasting during dialysis. VLF evaluation may provide information that can be used to develop a more reasonable intradialytic nutritional supplementation method.