Schmidt´s syndrome found by tan: a case report

Addison´s disease can form part of type 2 autoimmune polyglandular syndrome. The article reports the case of a 41-year-old female patient with hypothyroidism and vitiligo, who came to the emergency department complaining of asthenia that had worsened in recent months, as well as anorexia, nausea, an...

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Bibliographic Details
Published in:The Pan African medical journal 2024, Vol.48, p.53
Main Authors: Venade, Gabriela, Almeida, Catarina, Oliveira, Nídia, Matos, Luis Costa
Format: Article
Language:English
Subjects:
Addison Disease - complications
Addison Disease - diagnosis
Addison Disease - drug therapy
Adrenocorticotropic Hormone
Adult
Case Report
Female
Fludrocortisone - administration & dosage
Fludrocortisone - therapeutic use
Glucocorticoids - administration & dosage
Humans
Hydrocortisone - administration & dosage
Hyperpigmentation - diagnosis
Hyperpigmentation - etiology
Hypothyroidism - diagnosis
Hypothyroidism - drug therapy
Polyendocrinopathies, Autoimmune - complications
Polyendocrinopathies, Autoimmune - diagnosis
Polyendocrinopathies, Autoimmune - drug therapy
Prednisolone - administration & dosage
Vitiligo - diagnosis
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Summary:Addison´s disease can form part of type 2 autoimmune polyglandular syndrome. The article reports the case of a 41-year-old female patient with hypothyroidism and vitiligo, who came to the emergency department complaining of asthenia that had worsened in recent months, as well as anorexia, nausea, and weight loss (6 kg in a year). Cutaneous hyperpigmentation was the main finding on physical examination, together with vitiligo lesions on the face, hands, and armpits. Further study revealed a low serum cortisol level, normal urine-free cortisol, and an elevated adrenocorticotropic hormone (ACTH). Antiperoxidase antibodies and 17-alpha-hidroxylase antibodies were both positive. Treatment was started with prednisolone and fludrocortisone, and a good clinical response was obtained. This case report aims to draw attention to the high level of clinical suspicion required to diagnose Addison´s disease and the need to screen actively for other potentially associated autoimmune diseases that may be associated.
ISSN:1937-8688
1937-8688
DOI:10.11604/pamj.2024.48.53.35130