Carotenoid pattern intake and relation to metabolic status, risk and syndrome, and its components – divergent findings from the ORISCAV-LUX-2 survey

• Published in: British journal of nutrition 2024-07, Vol.132 (1), p.50-66
• Main Authors: Bouayed, Jaouad, Vahid, Farhad
• Format: Article
• Language: English
• Subjects: Adult; Adults; Aged; beta Carotene - administration & dosage; Blood pressure; Body Mass Index; Carotene; Carotenoids; Carotenoids - administration & dosage; Cholesterol; Convenience foods; Cross-Sectional Studies; Diabetes; Diet; Dietary intake; Disease; Exercise; Female; Food; Food intake; Fruit; Fruit juices; Fruits; High density lipoprotein; Human and Clinical Nutrition; Humans; Lutein - administration & dosage; Lutein - blood; Luxembourg; Lycopene; Lycopene - administration & dosage; Male; Meta-analysis; Metabolic disorders; Metabolic Syndrome; Metabolites; Middle Aged; Oxidative stress; Polyphenols; Prepared foods; Regression analysis; Regression models; Risk Factors; Sociodemographics; Tomatoes; Vegetables; Waist Circumference; Zeaxanthin; Zeaxanthins - administration & dosage; Zeaxanthins - blood; β-Carotene
• ISSN: 0007-1145; 1475-2662; 1475-2662
• DOI: 10.1017/S0007114524000758

Carotenoids are generally associated with health-beneficial effects; however, their intake patterns related to the metabolic syndrome (MetS) and its components remain controversial. This cross-sectional study investigated associations between dietary intakes of individual carotenoids, fruits and vegetables, and the MetS and its components. Dietary intakes of 1346 participants of the Observation des Risques et de la Santé Cardio-Vasculaire au Luxembourg (ORISCAV-LUX-2) study were investigated by a 174-item FFQ, and carotenoid intake was determined by linking findings using mainly the USDA food databases. Components of MetS and complementary variables, including anthropometric (BMI, waist circumferences and waist:hip ratio) and biological parameters (TAG, HDL-cholesterol, fasting blood glucose and blood pressure), were measured. Logistic (for MetS) and linear multivariable regression models (including assessing MetS as scores) adjusted for various confounders were created. α-and β-Carotene, as well as lutein + zeaxanthin, were inversely associated with MetS (also when it was measured on a continuous scale), reducing the odds for MetS by up to 48 %. However, lycopene, phytoene and phytofluene were rather positively associated with MetS scores and its components, though these adverse effects disappeared, at least for lycopene, when controlling for intakes of tomato-based convenience foods, in line with indicating a rather unhealthy/westernised diet. All these associations remained significant when including fruits and vegetables as confounders, suggesting that carotenoids were related to MetS independently from effects within fruits and vegetables. Thus, a high intake of carotenoids was bidirectionally associated with MetS, its severity, risk and its components, depending on the type of carotenoid. Future investigations are warranted to explore the inverse role that tomato-based carotenoids appear to suggest in relation to the MetS.