Clinical signs and hematologic, cytokine, and plasma nitric oxide alterations in response to Strongylus vulgaris infection in helminth-naive ponies

The objective of this study was to determine the effect of infection with Strongylus vulgaris on serum cytokines and plasma nitric oxide (NO) concentrations in helminth-naive ponies. Group 1 (n = 21) was given 500 S. vulgaris L3 larvae and group 2 (n = 7) received a saline control. Ponies were monit...

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Bibliographic Details
Published in:Canadian journal of veterinary research 2004-07, Vol.68 (3), p.193-200
Main Authors: Hubert, J.D, Seahorn, T.L, Klei, T.R, Hosgood, G, Horohov, D.W, Moore, R.M
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
blood plasma
Cytokines - blood
Erythrocyte Count - veterinary
Female
Horses
inflammation
interleukin-1
Interleukin-1 - blood
interleukin-6
Interleukin-6 - blood
Leukocyte Count - veterinary
Male
Nitric Oxide - blood
Strongyle Infections, Equine - blood
Strongyle Infections, Equine - immunology
Strongylus - immunology
Strongylus - pathogenicity
tumor necrosis factors
young animals
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Summary:The objective of this study was to determine the effect of infection with Strongylus vulgaris on serum cytokines and plasma nitric oxide (NO) concentrations in helminth-naive ponies. Group 1 (n = 21) was given 500 S. vulgaris L3 larvae and group 2 (n = 7) received a saline control. Ponies were monitored daily for clinical signs, and blood was collected for complete blood cell counts and serum cytokines (TNF, IL-1, IL-6) quantification. Group 1 ponies were depressed, anorexic, and febrile for variable periods of time. Plasma NO was increased on day 21 in group 1 and on days 9 and 21 in group 2. Significant increases in total white blood cell counts, fibrinogen, and plasma protein concentrations in group 1 were found. Significant decreases in red blood cell counts and packed cell volume were also noted in group 1. There were no differences in serum cytokines across time in either group of ponies. Despite the lack of proinflammatory cytokine induction with the apparent inflammatory response to S. vulgaris there is evidence of a potential role of NO.
ISSN:0830-9000