Loading…
Changes in cerebral vascular reactivity following mild repetitive head injury in awake rats: modeling the human experience
The changes in brain function in response to mild head injury are usually subtle and go undetected. Physiological biomarkers would aid in the early diagnosis of mild head injury. In this study we used hypercapnia to follow changes in cerebral vascular reactivity after repetitive mild head injury. We...
Saved in:
Published in: | Experimental brain research 2024-10, Vol.242 (10), p.2433-2442 |
---|---|
Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | |
---|---|
cites | cdi_FETCH-LOGICAL-c356t-91935210bfa7e85bb1d2c16c5ff837140d7963e2314aa9c0a6a836a1b83e17b63 |
container_end_page | 2442 |
container_issue | 10 |
container_start_page | 2433 |
container_title | Experimental brain research |
container_volume | 242 |
creator | Bens, Nicole Kulkarni, Praveen Ferris, Craig F. |
description | The changes in brain function in response to mild head injury are usually subtle and go undetected. Physiological biomarkers would aid in the early diagnosis of mild head injury. In this study we used hypercapnia to follow changes in cerebral vascular reactivity after repetitive mild head injury. We hypothesized head injury would reduce vascular reactivity. Rats were maintained on a reverse light-dark cycle and head impacted daily at 24 h intervals over three days. All head impacts were delivered while rats were fully awake under red light illumination. There was no neuroradiological evidence of brain damage. After the 3rd impact rats were exposed to 5% CO
2
and imaged for changes in BOLD signal. All imaging was done while rats were awake without the confound of anesthesia. The data were registered to a 3D MRI rat atlas with 171 segmented brain areas providing site specific information on vascular reactivity. The changes in vascular reactivity were not uniform across the brain. The prefrontal cortex, somatosensory cortex and basal ganglia showed the hypothesized decrease in vascular reactivity while the cerebellum, thalamus, brainstem, and olfactory system showed an increase in BOLD signal to hypercapnia. |
doi_str_mv | 10.1007/s00221-024-06907-7 |
format | article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11422282</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3094826807</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-91935210bfa7e85bb1d2c16c5ff837140d7963e2314aa9c0a6a836a1b83e17b63</originalsourceid><addsrcrecordid>eNp9kUuP0zAUhS0EYsrAH2CBLLFhE7jXTm2HDUIVL2kkNrC2HOemdcmj2EmH8utx6DA8Fqws63zn2EeHsccIzxFAv0gAQmABoixAVaALfYetsJSiQAR1l60AsCxKg9UFe5DSfrlKDffZhaxQCS2qFfu-2blhS4mHgXuKVEfX8aNLfu5c5JGcn8IxTCfejl03Xodhy_vQNVk50BSyRnxHrsn2_RxPS4q7dl-IRzell7wfG-oWz7TL3Ny7gdO3A8VAg6eH7F7rukSPbs5L9vntm0-b98XVx3cfNq-vCi_XaioqrORaINSt02TWdY2N8Kj8um2N1FhCoyslSUgsnas8OOWMVA5rIwl1reQle3XOPcx1T42nYcol7SGG3sWTHV2wfytD2NnteLSIpRDCiJzw7CYhjl9nSpPtQ_LUdW6gcU5WQlUaoQzojD79B92PcxxyPysRjClRrCFT4kz5OKYUqb39DYJdtrXnbW3e1v7c1i7RT_7scWv5NWYG5BlIWcqjxt9v_yf2B4DEsUo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3108841250</pqid></control><display><type>article</type><title>Changes in cerebral vascular reactivity following mild repetitive head injury in awake rats: modeling the human experience</title><source>Springer Link</source><creator>Bens, Nicole ; Kulkarni, Praveen ; Ferris, Craig F.</creator><creatorcontrib>Bens, Nicole ; Kulkarni, Praveen ; Ferris, Craig F.</creatorcontrib><description>The changes in brain function in response to mild head injury are usually subtle and go undetected. Physiological biomarkers would aid in the early diagnosis of mild head injury. In this study we used hypercapnia to follow changes in cerebral vascular reactivity after repetitive mild head injury. We hypothesized head injury would reduce vascular reactivity. Rats were maintained on a reverse light-dark cycle and head impacted daily at 24 h intervals over three days. All head impacts were delivered while rats were fully awake under red light illumination. There was no neuroradiological evidence of brain damage. After the 3rd impact rats were exposed to 5% CO
2
and imaged for changes in BOLD signal. All imaging was done while rats were awake without the confound of anesthesia. The data were registered to a 3D MRI rat atlas with 171 segmented brain areas providing site specific information on vascular reactivity. The changes in vascular reactivity were not uniform across the brain. The prefrontal cortex, somatosensory cortex and basal ganglia showed the hypothesized decrease in vascular reactivity while the cerebellum, thalamus, brainstem, and olfactory system showed an increase in BOLD signal to hypercapnia.</description><identifier>ISSN: 0014-4819</identifier><identifier>ISSN: 1432-1106</identifier><identifier>EISSN: 1432-1106</identifier><identifier>DOI: 10.1007/s00221-024-06907-7</identifier><identifier>PMID: 39162729</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Anesthesia ; Animals ; Basal ganglia ; Biomedical and Life Sciences ; Biomedicine ; Brain - diagnostic imaging ; Brain - physiopathology ; Brain injury ; Brain stem ; Carbon dioxide ; Cerebellum ; Cerebrovascular Circulation - physiology ; Cortex (olfactory) ; Disease Models, Animal ; Early experience ; Head ; Head injuries ; Hypercapnia ; Hypercapnia - physiopathology ; Magnetic Resonance Imaging ; Male ; Neuroimaging ; Neurology ; Neurosciences ; Olfactory system ; Oxygen - blood ; Prefrontal cortex ; Rats ; Rats, Sprague-Dawley ; Research Article ; Somatosensory cortex ; Wakefulness - physiology</subject><ispartof>Experimental brain research, 2024-10, Vol.242 (10), p.2433-2442</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c356t-91935210bfa7e85bb1d2c16c5ff837140d7963e2314aa9c0a6a836a1b83e17b63</cites><orcidid>0000-0001-9744-5214</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39162729$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bens, Nicole</creatorcontrib><creatorcontrib>Kulkarni, Praveen</creatorcontrib><creatorcontrib>Ferris, Craig F.</creatorcontrib><title>Changes in cerebral vascular reactivity following mild repetitive head injury in awake rats: modeling the human experience</title><title>Experimental brain research</title><addtitle>Exp Brain Res</addtitle><addtitle>Exp Brain Res</addtitle><description>The changes in brain function in response to mild head injury are usually subtle and go undetected. Physiological biomarkers would aid in the early diagnosis of mild head injury. In this study we used hypercapnia to follow changes in cerebral vascular reactivity after repetitive mild head injury. We hypothesized head injury would reduce vascular reactivity. Rats were maintained on a reverse light-dark cycle and head impacted daily at 24 h intervals over three days. All head impacts were delivered while rats were fully awake under red light illumination. There was no neuroradiological evidence of brain damage. After the 3rd impact rats were exposed to 5% CO
2
and imaged for changes in BOLD signal. All imaging was done while rats were awake without the confound of anesthesia. The data were registered to a 3D MRI rat atlas with 171 segmented brain areas providing site specific information on vascular reactivity. The changes in vascular reactivity were not uniform across the brain. The prefrontal cortex, somatosensory cortex and basal ganglia showed the hypothesized decrease in vascular reactivity while the cerebellum, thalamus, brainstem, and olfactory system showed an increase in BOLD signal to hypercapnia.</description><subject>Anesthesia</subject><subject>Animals</subject><subject>Basal ganglia</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - physiopathology</subject><subject>Brain injury</subject><subject>Brain stem</subject><subject>Carbon dioxide</subject><subject>Cerebellum</subject><subject>Cerebrovascular Circulation - physiology</subject><subject>Cortex (olfactory)</subject><subject>Disease Models, Animal</subject><subject>Early experience</subject><subject>Head</subject><subject>Head injuries</subject><subject>Hypercapnia</subject><subject>Hypercapnia - physiopathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Olfactory system</subject><subject>Oxygen - blood</subject><subject>Prefrontal cortex</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Research Article</subject><subject>Somatosensory cortex</subject><subject>Wakefulness - physiology</subject><issn>0014-4819</issn><issn>1432-1106</issn><issn>1432-1106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kUuP0zAUhS0EYsrAH2CBLLFhE7jXTm2HDUIVL2kkNrC2HOemdcmj2EmH8utx6DA8Fqws63zn2EeHsccIzxFAv0gAQmABoixAVaALfYetsJSiQAR1l60AsCxKg9UFe5DSfrlKDffZhaxQCS2qFfu-2blhS4mHgXuKVEfX8aNLfu5c5JGcn8IxTCfejl03Xodhy_vQNVk50BSyRnxHrsn2_RxPS4q7dl-IRzell7wfG-oWz7TL3Ny7gdO3A8VAg6eH7F7rukSPbs5L9vntm0-b98XVx3cfNq-vCi_XaioqrORaINSt02TWdY2N8Kj8um2N1FhCoyslSUgsnas8OOWMVA5rIwl1reQle3XOPcx1T42nYcol7SGG3sWTHV2wfytD2NnteLSIpRDCiJzw7CYhjl9nSpPtQ_LUdW6gcU5WQlUaoQzojD79B92PcxxyPysRjClRrCFT4kz5OKYUqb39DYJdtrXnbW3e1v7c1i7RT_7scWv5NWYG5BlIWcqjxt9v_yf2B4DEsUo</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Bens, Nicole</creator><creator>Kulkarni, Praveen</creator><creator>Ferris, Craig F.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9744-5214</orcidid></search><sort><creationdate>20241001</creationdate><title>Changes in cerebral vascular reactivity following mild repetitive head injury in awake rats: modeling the human experience</title><author>Bens, Nicole ; Kulkarni, Praveen ; Ferris, Craig F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-91935210bfa7e85bb1d2c16c5ff837140d7963e2314aa9c0a6a836a1b83e17b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anesthesia</topic><topic>Animals</topic><topic>Basal ganglia</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - physiopathology</topic><topic>Brain injury</topic><topic>Brain stem</topic><topic>Carbon dioxide</topic><topic>Cerebellum</topic><topic>Cerebrovascular Circulation - physiology</topic><topic>Cortex (olfactory)</topic><topic>Disease Models, Animal</topic><topic>Early experience</topic><topic>Head</topic><topic>Head injuries</topic><topic>Hypercapnia</topic><topic>Hypercapnia - physiopathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Neuroimaging</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Olfactory system</topic><topic>Oxygen - blood</topic><topic>Prefrontal cortex</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Research Article</topic><topic>Somatosensory cortex</topic><topic>Wakefulness - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bens, Nicole</creatorcontrib><creatorcontrib>Kulkarni, Praveen</creatorcontrib><creatorcontrib>Ferris, Craig F.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Experimental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bens, Nicole</au><au>Kulkarni, Praveen</au><au>Ferris, Craig F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in cerebral vascular reactivity following mild repetitive head injury in awake rats: modeling the human experience</atitle><jtitle>Experimental brain research</jtitle><stitle>Exp Brain Res</stitle><addtitle>Exp Brain Res</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>242</volume><issue>10</issue><spage>2433</spage><epage>2442</epage><pages>2433-2442</pages><issn>0014-4819</issn><issn>1432-1106</issn><eissn>1432-1106</eissn><abstract>The changes in brain function in response to mild head injury are usually subtle and go undetected. Physiological biomarkers would aid in the early diagnosis of mild head injury. In this study we used hypercapnia to follow changes in cerebral vascular reactivity after repetitive mild head injury. We hypothesized head injury would reduce vascular reactivity. Rats were maintained on a reverse light-dark cycle and head impacted daily at 24 h intervals over three days. All head impacts were delivered while rats were fully awake under red light illumination. There was no neuroradiological evidence of brain damage. After the 3rd impact rats were exposed to 5% CO
2
and imaged for changes in BOLD signal. All imaging was done while rats were awake without the confound of anesthesia. The data were registered to a 3D MRI rat atlas with 171 segmented brain areas providing site specific information on vascular reactivity. The changes in vascular reactivity were not uniform across the brain. The prefrontal cortex, somatosensory cortex and basal ganglia showed the hypothesized decrease in vascular reactivity while the cerebellum, thalamus, brainstem, and olfactory system showed an increase in BOLD signal to hypercapnia.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>39162729</pmid><doi>10.1007/s00221-024-06907-7</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-9744-5214</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0014-4819 |
ispartof | Experimental brain research, 2024-10, Vol.242 (10), p.2433-2442 |
issn | 0014-4819 1432-1106 1432-1106 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11422282 |
source | Springer Link |
subjects | Anesthesia Animals Basal ganglia Biomedical and Life Sciences Biomedicine Brain - diagnostic imaging Brain - physiopathology Brain injury Brain stem Carbon dioxide Cerebellum Cerebrovascular Circulation - physiology Cortex (olfactory) Disease Models, Animal Early experience Head Head injuries Hypercapnia Hypercapnia - physiopathology Magnetic Resonance Imaging Male Neuroimaging Neurology Neurosciences Olfactory system Oxygen - blood Prefrontal cortex Rats Rats, Sprague-Dawley Research Article Somatosensory cortex Wakefulness - physiology |
title | Changes in cerebral vascular reactivity following mild repetitive head injury in awake rats: modeling the human experience |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T08%3A49%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Changes%20in%20cerebral%20vascular%20reactivity%20following%20mild%20repetitive%20head%20injury%20in%20awake%20rats:%20modeling%20the%20human%20experience&rft.jtitle=Experimental%20brain%20research&rft.au=Bens,%20Nicole&rft.date=2024-10-01&rft.volume=242&rft.issue=10&rft.spage=2433&rft.epage=2442&rft.pages=2433-2442&rft.issn=0014-4819&rft.eissn=1432-1106&rft_id=info:doi/10.1007/s00221-024-06907-7&rft_dat=%3Cproquest_pubme%3E3094826807%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c356t-91935210bfa7e85bb1d2c16c5ff837140d7963e2314aa9c0a6a836a1b83e17b63%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3108841250&rft_id=info:pmid/39162729&rfr_iscdi=true |