The promising antioxidant effects of lignans: Nrf2 activation comes into view

Lignans are biologically active compounds widely distributed, recognized, and identified in seeds, fruits, and vegetables. Lignans have several intriguing bioactivities, including anti-inflammatory, antioxidant, and anticancer activities. Nrf2 controls the expression of many cytoprotective genes. Ac...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 2024-09, Vol.397 (9), p.6439-6458
Main Authors: Hassanein, Emad H. M., Althagafy, Hanan S., Baraka, Mohammad A., Abd-alhameed, Esraa K., Ibrahim, Islam M., Abd El-Maksoud, Mostafa S., Mohamed, Nesma M., Ross, Samir A.
Format: Article
Language:English
Subjects:
Animal models
Animals
Anti-inflammatory agents
Anti-Inflammatory Agents - pharmacology
Antioxidants
Antioxidants - pharmacology
Archives & records
Bioactive compounds
Biological activity
Biomedical and Life Sciences
Biomedicine
Cancer
Cardiovascular disease
Disease prevention
Feces
Humans
Inflammation
Lignans - pharmacology
Metabolites
Neurosciences
NF-E2-Related Factor 2 - metabolism
Oxidative Stress - drug effects
Pharmacology
Pharmacology/Toxicology
Pharmacy
Polyphenols
Review
Seeds
Signal Transduction - drug effects
Steroids
Toxicology
Transcription activation
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Summary:Lignans are biologically active compounds widely distributed, recognized, and identified in seeds, fruits, and vegetables. Lignans have several intriguing bioactivities, including anti-inflammatory, antioxidant, and anticancer activities. Nrf2 controls the expression of many cytoprotective genes. Activation of Nrf2 is a promising therapeutic approach for treating and preventing diseases resulting from oxidative injury and inflammation. Lignans have been demonstrated to stimulate Nrf2 signaling in a variety of in vitro and experimental animal models. The review summarizes the findings of fourteen lignans (Schisandrin A, Schisandrin B, Schisandrian C, Magnolol, Honokiol, Sesamin, Sesamol, Sauchinone, Pinoresinol, Phyllanthin, Nectandrin B, Isoeucommin A, Arctigenin, Lariciresinol) as antioxidative and anti-inflammatory agents, affirming how Nrf2 activation affects their pharmacological effects. Therefore, lignans may offer therapeutic candidates for the treatment and prevention of various diseases and may contribute to the development of effective Nrf2 modulators.
ISSN:0028-1298
1432-1912
1432-1912
DOI:10.1007/s00210-024-03102-x