Cardiac Autonomic Neuropathy in Diabetic Peripheral Neuropathy

Background Cardiac autonomic neuropathy (CAN) is the most underdiagnosed consequence of diabetes because standard hospital settings do not provide consistent diagnostic criteria or testing resources. It is still unclear how diabetic peripheral neuropathy (DPN) and CAN are related. Therefore, this st...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-08, Vol.16 (8), p.e67777
Main Authors: Naik, Balaji, Pandey, Abhishek, Dasgupta, Riddhi, Shivaprasad, Channabasappa
Format: Article
Language:English
Subjects:
Blood pressure
Cardiovascular disease
Diabetes
Electrocardiography
Endocrinology/Diabetes/Metabolism
Glucose
Heart rate
Kinases
Mortality
Nervous system
Patients
Peripheral neuropathy
Plasma
Questionnaires
Ratios
Statistical analysis
Variables
Variance analysis
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Summary:Background Cardiac autonomic neuropathy (CAN) is the most underdiagnosed consequence of diabetes because standard hospital settings do not provide consistent diagnostic criteria or testing resources. It is still unclear how diabetic peripheral neuropathy (DPN) and CAN are related. Therefore, this study aimed to determine the prevalence of CAN in individuals with type 2 diabetes mellitus who had isolated DPN without other microvascular or macrovascular complications. Methodology A total of 35 type 2 diabetes mellitus patients with isolated DPN (group 1) and an equal number of sex- and age-matched patients without DPN (group 2) underwent CAN testing. Results were compared between the two groups. Results A significantly higher prevalence of isolated parasympathetic (28.57 vs. 11.42%), isolated sympathetic (22.85 vs. 8.57%), and combined autonomic dysfunction (37.14 vs. 2.85%) was found in the neuropathic group compared to the non-neuropathic group. Group 1 exhibited more abnormal parasympathetic nervous system test results and increased diastolic pressure during sustained handgrip compared to group 2 (all p-values
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.67777