Omega-3 fatty acids in primary and secondary prevention of cardiovascular diseases

Even with substantial progress in primary and secondary prevention, cardiovascular disease (CVD) persists as a major cause of mortality and morbidity globally. Omega-3 polyunsaturated fatty acids (Ω-3 PUFAs) have gained considerable attention for their ability to improve CV health and prognosis. Met...

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Bibliographic Details
Published in:Progress in cardiovascular diseases 2024-05, Vol.84, p.19-26
Main Authors: Tutor, Austin, O'Keefe, Evan L., Lavie, Carl J., Elagizi, Andrew, Milani, Richard, O'Keefe, James
Format: Article
Language:English
Subjects:
Cardiovascular disease
Fish oil
Myocardial infarction
Omega-3 polyunsaturated fatty acids
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Summary:Even with substantial progress in primary and secondary prevention, cardiovascular disease (CVD) persists as a major cause of mortality and morbidity globally. Omega-3 polyunsaturated fatty acids (Ω-3 PUFAs) have gained considerable attention for their ability to improve CV health and prognosis. Metanalyses of randomized controlled trials have demonstrated Ω-3 PUFAs' positive impact on CVD outcomes for both primary and secondary prevention endpoints. Marine Ω-3 PUFAs also improve CVD risk factors including blood pressure, lipids, and inflammation; however, many physicians do not recommend Ω-3 PUFAs, largely due to inconsistent results in randomized trials. In this comprehensive review article, we evaluate both historic and current data concerning primary and secondary prevention of CVD with use of Ω-3 PUFAs, delve into the potential causes for the varied results, and examine the most current recommendations on the usage of Ω-3 PUFAs.
ISSN:0033-0620
1532-8643
1873-1740
DOI:10.1016/j.pcad.2024.03.009