Transrectal versus transperineal prostate fusion biopsy: a pair-matched analysis to evaluate accuracy and complications

Purpose To evaluate biopsy-related complications and detection rates of any PCa and clinically significant PCa (csPCa, intended as grade group ≥ 2) between MRI-targeted TP fusion biopsies (TPBx) and TR ones (TRBx). Methods We performed a multicentric study on 4841 patients who underwent fusion biops...

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Bibliographic Details
Published in:World journal of urology 2024-09, Vol.42 (1), p.535, Article 535
Main Authors: Oderda, Marco, Diamand, Romain, Abou Zahr, Rawad, Anract, Julien, Assenmacher, Gregoire, Barry Delongchamps, Nicolas, Bui, Alexandre Patrick, Benamran, Daniel, Calleris, Giorgio, Dariane, Charles, Ferriero, Mariaconsiglia, Fiard, Gaelle, Taha, Fayek, Fourcade, Alexandre, Fournier, Georges, Guenzel, Karsten, Halinski, Adam, Marra, Giancarlo, Ploussard, Guillaume, Rysankova, Katerina, Roche, Jean-Baptiste, Simone, Giuseppe, Windisch, Olivier, Gontero, Paolo
Format: Article
Language:English
Subjects:
Aged
Antibiotics
Biopsy
Case-Control Studies
Disease prevention
Humans
Image-Guided Biopsy - adverse effects
Image-Guided Biopsy - methods
Magnetic Resonance Imaging
Male
Matched-Pair Analysis
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Oncology
Perineum
Postoperative Complications - epidemiology
Prophylaxis
Prostate - pathology
Prostatic Neoplasms - pathology
Rectum
Reproducibility of Results
Retrospective Studies
Urology
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Summary:Purpose To evaluate biopsy-related complications and detection rates of any PCa and clinically significant PCa (csPCa, intended as grade group ≥ 2) between MRI-targeted TP fusion biopsies (TPBx) and TR ones (TRBx). Methods We performed a multicentric study on 4841 patients who underwent fusion biopsy between 2016 and 2023. A case–control matching was performed to find comparable cohorts of 646 TPBx and 646 TRBx. Mean T test and Pearson chi-square tests were used to compare continuous and categorical variables. Results Baseline characteristics were comparable between the cohorts, except for target location with a higher rate of anterior lesions in TPBx group. Complications were rare and no difference was found between the groups, with similar rates of infections after TRBx and TPBx (N = 5 (0.8%) vs N = 2 (0.3%), p 0.45). All patients in TRBx and 90.1% in TPBx group received antibiotic prophylaxis. A higher csPCa detection rate was found in TPBx over the group (50.5% vs 36.2%, p 
ISSN:1433-8726
0724-4983
1433-8726
DOI:10.1007/s00345-024-05245-1