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Maintenance of neuronal positions in organized ganglia by SAX-7, a Caenorhabditis elegans homologue of L1

The L1 family of cell adhesion molecules is predominantly expressed in the nervous system. Mutations in human L1 cause neuronal diseases such as HSAS, MASA, and SPG1. Here we show that sax‐7 gene encodes an L1 homologue in Caenorhabditis elegans . In sax‐7 mutants, the organization of ganglia and po...

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Published in:The EMBO journal 2005-04, Vol.24 (7), p.1477-1488
Main Authors: Sasakura, Hiroyuki, Inada, Hitoshi, Kuhara, Atsushi, Fusaoka, Eri, Takemoto, Daisuke, Takeuchi, Kosei, Mori, Ikue
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cited_by cdi_FETCH-LOGICAL-c6701-38626b7fe7cd93c2a4d2d62d7ec9c88a17c1ccf2b3471be71b659a498a20a8313
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Mori, Ikue
description The L1 family of cell adhesion molecules is predominantly expressed in the nervous system. Mutations in human L1 cause neuronal diseases such as HSAS, MASA, and SPG1. Here we show that sax‐7 gene encodes an L1 homologue in Caenorhabditis elegans . In sax‐7 mutants, the organization of ganglia and positioning of neurons are abnormal in the adult stage, but these abnormalities are not observed in early larval stage. Misplacement of neurons in sax‐7 mutants is triggered by mechanical force linked to body movement. Short and long forms of SAX‐7 exhibited strong and weak homophilic adhesion activities in in vitro aggregation assay, respectively, which correlated with their different activities in vivo . SAX‐7 was localized on plasma membranes of neurons in vivo . Expression of SAX‐7 only in a single neuron in sax‐7 mutants cell‐autonomously restored its normal neuronal position. Expression of SAX‐7 in two different head neurons in sax‐7 mutants led to the forced attachment of these neurons. We propose that both homophilic and heterophilic interactions of SAX‐7 are essential for maintenance of neuronal positions in organized ganglia.
doi_str_mv 10.1038/sj.emboj.7600621
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subjects Adhesion
Animals
Baculoviridae
Blotting, Western
Bombyx
C. elegans
Caenorhabditis elegans
Caenorhabditis elegans - metabolism
Caenorhabditis elegans Proteins - genetics
Caenorhabditis elegans Proteins - metabolism
Cell Adhesion - physiology
Cell Aggregation - genetics
Cell Aggregation - physiology
Cells, Cultured
Cloning, Molecular
DNA, Complementary - genetics
EMBO11
EMBO27
Ganglia, Invertebrate - metabolism
Gene Components
Genetic Vectors
Green Fluorescent Proteins
L1 family
Membrane Proteins - metabolism
Models, Biological
Mutants
Mutation
Mutation - genetics
Neural Cell Adhesion Molecule L1 - genetics
Neural Cell Adhesion Molecules - genetics
Neural Cell Adhesion Molecules - metabolism
neuronal adhesion
neuronal placement
Neurons - metabolism
organization of ganglia
Phylogeny
title Maintenance of neuronal positions in organized ganglia by SAX-7, a Caenorhabditis elegans homologue of L1
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