Leucocyte Telomere Length and Lung Cancer Risk: A Systematic Review and Meta-Analysis of Prospective Studies

Although numerous epidemiological studies are available, the relationship between leukocyte telomere length (LTL) and lung cancer risk is still controversial. This systematic review and meta-analysis, performed according to the PRISMA statement and MOOSE guidelines, aims to summarize the evidence an...

Full description

Saved in:
Bibliographic Details
Published in:Cancers 2024-09, Vol.16 (18), p.3218
Main Authors: Fabiani, Roberto, Chiavarini, Manuela, Rosignoli, Patrizia, Giacchetta, Irene
Format: Article
Language:English
Subjects:
Air pollution
Cancer
Carcinogenesis
Cell division
Cohort analysis
Development and progression
Disease
Epidemiology
Estimates
Genetic testing
Genomic analysis
Genomic instability
Leukocytes
Lung cancer
Medical diagnosis
Meta-analysis
Mortality
Oncology, Experimental
Prostate
Risk factors
Sensitivity analysis
Squamous cell carcinoma
Systematic Review
Telomerase
Telomeres
Tumorigenesis
Yeast
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although numerous epidemiological studies are available, the relationship between leukocyte telomere length (LTL) and lung cancer risk is still controversial. This systematic review and meta-analysis, performed according to the PRISMA statement and MOOSE guidelines, aims to summarize the evidence and calculate the risk of lung cancer associated with LTL. The literature search was performed on PubMed, Web of Science, and Scopus databases through May 2024. A random-effects model was used to calculate the pooled risk. Heterogeneity was assessed using I and Cochran's Q statistic. Begg's and Egger's tests were used to detect publication bias. Based on 8055 lung cancer cases and 854,653 controls (nine prospective studies), longer LTL was associated with a significant 42% increment in all types of lung cancer risk (OR 1.42, 95% CI 1.24-1.63). The effect was even more evident for adenocarcinomas (OR 1.98, 95% CI 1.69-2.31), while no association was observed for squamous cell carcinoma (OR 0.87, 95% CI 0.72-1.06). Significantly, no association was found for current smokers (OR 1.08, 95% CI 0.90-1.30), while it remained high for both never-smokers (OR 1.92, 95% CI 1.62-2.28) and former smokers (OR 1.34, 95% CI 1.11-1.62). No significant publication bias was evidenced. Longer LTL is associated with an increment in lung cancer risk particularly in never-smoker subjects.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers16183218