Loading…
Atypical Spindle Cell/Pleomorphic Lipomatous Tumor: A Review and Update
Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare and recently described adipocytic neoplasm that primarily occurs in the subcutis of the limbs and limb girdles, particularly of middle-aged adults. It has locally recurrent potential if incompletely excised but no risk for distant...
Saved in:
| Published in: | Cancers 2024-09, Vol.16 (18), p.3146 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c373t-62e8b0b802c9c34c62d612c1f62e46963fab867f2d7727c6f596f27ff8c9194b3 |
| container_end_page | |
| container_issue | 18 |
| container_start_page | 3146 |
| container_title | Cancers |
| container_volume | 16 |
| creator | Nishio, Jun Nakayama, Shizuhide Chijiiwa, Yoshiro Koga, Mikiro Aoki, Mikiko |
| description | Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare and recently described adipocytic neoplasm that primarily occurs in the subcutis of the limbs and limb girdles, particularly of middle-aged adults. It has locally recurrent potential if incompletely excised but no risk for distant metastasis. ASCPLT is histologically similar to spindle cell/pleomorphic lipoma and atypical lipomatous tumor and shows a mixture of atypical spindle cells, adipocytes, lipoblasts, floret-like multinucleated giant cells, and/or pleomorphic cells. It has been recently recognized that ASCPLT can undergo sarcomatous transformation. However, the biological significance of morphological sarcomatous transformation in ASCPLT remains uncertain. Immunohistochemically, the tumor cells show variable expression of CD34, S-100 protein, and desmin. Loss of nuclear Rb expression is observed in the majority of cases. ASCPLT lacks
gene amplification but can show
gene deletion in a significant subset of cases. Complete surgical excision is the treatment of choice. This review provides an overview of the current knowledge on the clinicoradiological features, pathogenesis, histopathology, and treatment of ASCPLT. In addition, we will discuss the differential diagnosis of this new entity. |
| doi_str_mv | 10.3390/cancers16183146 |
| format | article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11430808</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A810842175</galeid><sourcerecordid>A810842175</sourcerecordid><originalsourceid>FETCH-LOGICAL-c373t-62e8b0b802c9c34c62d612c1f62e46963fab867f2d7727c6f596f27ff8c9194b3</originalsourceid><addsrcrecordid>eNptUU1PHSEUJU2bal5duzOTuHHzfFyYx4cb8_JirclL2lRdE4YBxczACDMa_32xflRNYQG595wD5x6EdgEfUirxwuhgbMrAQFCo2Se0TTAnc8Zk_fnNfQvt5HyDy6IUOONf0RaVlC4BxDY6XY0Pgze6q84HH9rOVmvbdYtfnY19TMO1N9XGD7HXY5xydTGV4lG1qn7bO2_vKx3a6nJo9Wi_oS9Od9nuPJ8zdPn95GL9Y775eXq2Xm3mhnI6zhmxosGNwMRIQ2vDSMuAGHClUTPJqNONYNyRlnPCDXNLyRzhzgkjQdYNnaHjJ91hanrbGhvGpDs1JN_r9KCi9up9J_hrdRXvFEBNscCiKBw8K6R4O9k8qt5nU0zrYItHRQGwLLMr_52h_Q_QmzilUPz9RdVACRP_UFe6s8oHF8vD5lFUrQRgURPgy4I6_A-q7Nb23sRgnS_1d4TFE8GkmHOy7tUkYPWYv_qQf2HsvZ3NK_4lbfoHhM6qHg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3110413268</pqid></control><display><type>article</type><title>Atypical Spindle Cell/Pleomorphic Lipomatous Tumor: A Review and Update</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Nishio, Jun ; Nakayama, Shizuhide ; Chijiiwa, Yoshiro ; Koga, Mikiro ; Aoki, Mikiko</creator><creatorcontrib>Nishio, Jun ; Nakayama, Shizuhide ; Chijiiwa, Yoshiro ; Koga, Mikiro ; Aoki, Mikiko</creatorcontrib><description>Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare and recently described adipocytic neoplasm that primarily occurs in the subcutis of the limbs and limb girdles, particularly of middle-aged adults. It has locally recurrent potential if incompletely excised but no risk for distant metastasis. ASCPLT is histologically similar to spindle cell/pleomorphic lipoma and atypical lipomatous tumor and shows a mixture of atypical spindle cells, adipocytes, lipoblasts, floret-like multinucleated giant cells, and/or pleomorphic cells. It has been recently recognized that ASCPLT can undergo sarcomatous transformation. However, the biological significance of morphological sarcomatous transformation in ASCPLT remains uncertain. Immunohistochemically, the tumor cells show variable expression of CD34, S-100 protein, and desmin. Loss of nuclear Rb expression is observed in the majority of cases. ASCPLT lacks
gene amplification but can show
gene deletion in a significant subset of cases. Complete surgical excision is the treatment of choice. This review provides an overview of the current knowledge on the clinicoradiological features, pathogenesis, histopathology, and treatment of ASCPLT. In addition, we will discuss the differential diagnosis of this new entity.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers16183146</identifier><identifier>PMID: 39335118</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adipocytes ; CD34 antigen ; Cell cycle ; Chromosomes ; Desmin ; Development and progression ; Differential diagnosis ; Gene amplification ; Gene deletion ; Genetic transformation ; Giant cells ; Histopathology ; Immunoreactivity ; Lipoma ; Liposarcoma ; Magnetic resonance imaging ; MDM2 protein ; Metastases ; Metastasis ; Morphology ; Neoplasia ; Pathogenesis ; Proteins ; Retinoblastoma protein ; Review ; S100 protein ; Tomography ; Tumor cells ; Tumors</subject><ispartof>Cancers, 2024-09, Vol.16 (18), p.3146</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c373t-62e8b0b802c9c34c62d612c1f62e46963fab867f2d7727c6f596f27ff8c9194b3</cites><orcidid>0000-0002-9902-1383 ; 0000-0001-9734-3496 ; 0000-0002-1876-0783 ; 0000-0002-0188-8000</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3110413268/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3110413268?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39335118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nishio, Jun</creatorcontrib><creatorcontrib>Nakayama, Shizuhide</creatorcontrib><creatorcontrib>Chijiiwa, Yoshiro</creatorcontrib><creatorcontrib>Koga, Mikiro</creatorcontrib><creatorcontrib>Aoki, Mikiko</creatorcontrib><title>Atypical Spindle Cell/Pleomorphic Lipomatous Tumor: A Review and Update</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare and recently described adipocytic neoplasm that primarily occurs in the subcutis of the limbs and limb girdles, particularly of middle-aged adults. It has locally recurrent potential if incompletely excised but no risk for distant metastasis. ASCPLT is histologically similar to spindle cell/pleomorphic lipoma and atypical lipomatous tumor and shows a mixture of atypical spindle cells, adipocytes, lipoblasts, floret-like multinucleated giant cells, and/or pleomorphic cells. It has been recently recognized that ASCPLT can undergo sarcomatous transformation. However, the biological significance of morphological sarcomatous transformation in ASCPLT remains uncertain. Immunohistochemically, the tumor cells show variable expression of CD34, S-100 protein, and desmin. Loss of nuclear Rb expression is observed in the majority of cases. ASCPLT lacks
gene amplification but can show
gene deletion in a significant subset of cases. Complete surgical excision is the treatment of choice. This review provides an overview of the current knowledge on the clinicoradiological features, pathogenesis, histopathology, and treatment of ASCPLT. In addition, we will discuss the differential diagnosis of this new entity.</description><subject>Adipocytes</subject><subject>CD34 antigen</subject><subject>Cell cycle</subject><subject>Chromosomes</subject><subject>Desmin</subject><subject>Development and progression</subject><subject>Differential diagnosis</subject><subject>Gene amplification</subject><subject>Gene deletion</subject><subject>Genetic transformation</subject><subject>Giant cells</subject><subject>Histopathology</subject><subject>Immunoreactivity</subject><subject>Lipoma</subject><subject>Liposarcoma</subject><subject>Magnetic resonance imaging</subject><subject>MDM2 protein</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Morphology</subject><subject>Neoplasia</subject><subject>Pathogenesis</subject><subject>Proteins</subject><subject>Retinoblastoma protein</subject><subject>Review</subject><subject>S100 protein</subject><subject>Tomography</subject><subject>Tumor cells</subject><subject>Tumors</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNptUU1PHSEUJU2bal5duzOTuHHzfFyYx4cb8_JirclL2lRdE4YBxczACDMa_32xflRNYQG595wD5x6EdgEfUirxwuhgbMrAQFCo2Se0TTAnc8Zk_fnNfQvt5HyDy6IUOONf0RaVlC4BxDY6XY0Pgze6q84HH9rOVmvbdYtfnY19TMO1N9XGD7HXY5xydTGV4lG1qn7bO2_vKx3a6nJo9Wi_oS9Od9nuPJ8zdPn95GL9Y775eXq2Xm3mhnI6zhmxosGNwMRIQ2vDSMuAGHClUTPJqNONYNyRlnPCDXNLyRzhzgkjQdYNnaHjJ91hanrbGhvGpDs1JN_r9KCi9up9J_hrdRXvFEBNscCiKBw8K6R4O9k8qt5nU0zrYItHRQGwLLMr_52h_Q_QmzilUPz9RdVACRP_UFe6s8oHF8vD5lFUrQRgURPgy4I6_A-q7Nb23sRgnS_1d4TFE8GkmHOy7tUkYPWYv_qQf2HsvZ3NK_4lbfoHhM6qHg</recordid><startdate>20240913</startdate><enddate>20240913</enddate><creator>Nishio, Jun</creator><creator>Nakayama, Shizuhide</creator><creator>Chijiiwa, Yoshiro</creator><creator>Koga, Mikiro</creator><creator>Aoki, Mikiko</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9902-1383</orcidid><orcidid>https://orcid.org/0000-0001-9734-3496</orcidid><orcidid>https://orcid.org/0000-0002-1876-0783</orcidid><orcidid>https://orcid.org/0000-0002-0188-8000</orcidid></search><sort><creationdate>20240913</creationdate><title>Atypical Spindle Cell/Pleomorphic Lipomatous Tumor: A Review and Update</title><author>Nishio, Jun ; Nakayama, Shizuhide ; Chijiiwa, Yoshiro ; Koga, Mikiro ; Aoki, Mikiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-62e8b0b802c9c34c62d612c1f62e46963fab867f2d7727c6f596f27ff8c9194b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adipocytes</topic><topic>CD34 antigen</topic><topic>Cell cycle</topic><topic>Chromosomes</topic><topic>Desmin</topic><topic>Development and progression</topic><topic>Differential diagnosis</topic><topic>Gene amplification</topic><topic>Gene deletion</topic><topic>Genetic transformation</topic><topic>Giant cells</topic><topic>Histopathology</topic><topic>Immunoreactivity</topic><topic>Lipoma</topic><topic>Liposarcoma</topic><topic>Magnetic resonance imaging</topic><topic>MDM2 protein</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Morphology</topic><topic>Neoplasia</topic><topic>Pathogenesis</topic><topic>Proteins</topic><topic>Retinoblastoma protein</topic><topic>Review</topic><topic>S100 protein</topic><topic>Tomography</topic><topic>Tumor cells</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nishio, Jun</creatorcontrib><creatorcontrib>Nakayama, Shizuhide</creatorcontrib><creatorcontrib>Chijiiwa, Yoshiro</creatorcontrib><creatorcontrib>Koga, Mikiro</creatorcontrib><creatorcontrib>Aoki, Mikiko</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Biological Sciences</collection><collection>ProQuest Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nishio, Jun</au><au>Nakayama, Shizuhide</au><au>Chijiiwa, Yoshiro</au><au>Koga, Mikiro</au><au>Aoki, Mikiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Atypical Spindle Cell/Pleomorphic Lipomatous Tumor: A Review and Update</atitle><jtitle>Cancers</jtitle><addtitle>Cancers (Basel)</addtitle><date>2024-09-13</date><risdate>2024</risdate><volume>16</volume><issue>18</issue><spage>3146</spage><pages>3146-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare and recently described adipocytic neoplasm that primarily occurs in the subcutis of the limbs and limb girdles, particularly of middle-aged adults. It has locally recurrent potential if incompletely excised but no risk for distant metastasis. ASCPLT is histologically similar to spindle cell/pleomorphic lipoma and atypical lipomatous tumor and shows a mixture of atypical spindle cells, adipocytes, lipoblasts, floret-like multinucleated giant cells, and/or pleomorphic cells. It has been recently recognized that ASCPLT can undergo sarcomatous transformation. However, the biological significance of morphological sarcomatous transformation in ASCPLT remains uncertain. Immunohistochemically, the tumor cells show variable expression of CD34, S-100 protein, and desmin. Loss of nuclear Rb expression is observed in the majority of cases. ASCPLT lacks
gene amplification but can show
gene deletion in a significant subset of cases. Complete surgical excision is the treatment of choice. This review provides an overview of the current knowledge on the clinicoradiological features, pathogenesis, histopathology, and treatment of ASCPLT. In addition, we will discuss the differential diagnosis of this new entity.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39335118</pmid><doi>10.3390/cancers16183146</doi><orcidid>https://orcid.org/0000-0002-9902-1383</orcidid><orcidid>https://orcid.org/0000-0001-9734-3496</orcidid><orcidid>https://orcid.org/0000-0002-1876-0783</orcidid><orcidid>https://orcid.org/0000-0002-0188-8000</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2072-6694 |
| ispartof | Cancers, 2024-09, Vol.16 (18), p.3146 |
| issn | 2072-6694 2072-6694 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11430808 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | Adipocytes CD34 antigen Cell cycle Chromosomes Desmin Development and progression Differential diagnosis Gene amplification Gene deletion Genetic transformation Giant cells Histopathology Immunoreactivity Lipoma Liposarcoma Magnetic resonance imaging MDM2 protein Metastases Metastasis Morphology Neoplasia Pathogenesis Proteins Retinoblastoma protein Review S100 protein Tomography Tumor cells Tumors |
| title | Atypical Spindle Cell/Pleomorphic Lipomatous Tumor: A Review and Update |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T17%3A27%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Atypical%20Spindle%20Cell/Pleomorphic%20Lipomatous%20Tumor:%20A%20Review%20and%20Update&rft.jtitle=Cancers&rft.au=Nishio,%20Jun&rft.date=2024-09-13&rft.volume=16&rft.issue=18&rft.spage=3146&rft.pages=3146-&rft.issn=2072-6694&rft.eissn=2072-6694&rft_id=info:doi/10.3390/cancers16183146&rft_dat=%3Cgale_pubme%3EA810842175%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c373t-62e8b0b802c9c34c62d612c1f62e46963fab867f2d7727c6f596f27ff8c9194b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3110413268&rft_id=info:pmid/39335118&rft_galeid=A810842175&rfr_iscdi=true |