Lactate/Pyruvate Ratio as an Early Predictor of Mortality in Patients with Sepsis: A Cohort Study

: The lactate/pyruvate (LP) ratio has been studied as an alternative to serum lactate to determine clinical prognosis. Despite its clinical utility, there is a paucity of evidence evaluating the role of the L/P ratio in patients with sepsis. : We assessed the clinical utility of the L/P ratio in pat...

Full description

Saved in:
Bibliographic Details
Published in:Journal of clinical medicine 2024-09, Vol.13 (18), p.5597
Main Authors: Cantu-Rodriguez, Olga G, Hawing-Zarate, Jose A, Dorsey-Trevino, Edgar G, Hernandez-Barajas, David, Villalobos-Gutierrez, Leonel E, Jaime-Perez, Jose Carlos, Mancias-Guerra, Consuelo, Gonzalez-Llano, Oscar, Gonzalez-Cantu, Graciela A, Gomez-Almaguer, David, Gutierrez-Aguirre, Cesar H
Format: Article
Language:English
Subjects:
Biomarkers
Blood gas analysis
Cohort analysis
Disease
Emergency medical care
Health aspects
Infections
Lactates
Length of stay
Medical research
Medicine, Experimental
Mortality
Patient outcomes
Patients
Physiological aspects
Pyruvates
Risk factors
Sepsis
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:: The lactate/pyruvate (LP) ratio has been studied as an alternative to serum lactate to determine clinical prognosis. Despite its clinical utility, there is a paucity of evidence evaluating the role of the L/P ratio in patients with sepsis. : We assessed the clinical utility of the L/P ratio in patients with sepsis. The L/P ratio was measured at baseline, 4 and 8 h after admission. Our primary outcome was to determine the prognostic utility of the L/P ratio on the 15-day mortality risk. Our secondary outcomes were to compare the L/P ratio across time and its prognostic utility against standard risk calculators such as APACHE-II and SOFA scores. : We had a total of 80 patients, with 18 (22.5%) survivors and 62 (77.5%) non-survivors. While we found that patients having higher L/P ratios at 8 h had an increased 30-mortality risk (OR 1.08, 95% CI 1.02-1.18), the model's performance showed no difference when compared to other measurements of the L/P ratio that showed no association with mortality ( -value: 0.45). For our secondary outcome, we found that the APACHE-II and SOFA scores have better performance and predictability than the L/P ratio (AUC 0.83 and AUC 0.80, respectively), but showed no association with mortality (OR 1.07, 95% CI 1.01-1.17 and OR 1.08, 95% CI 1.02-1.18). : Based on our findings, the L/P ratio appears to function more effectively as an early predictor of mortality when used as an adjuvant biomarker with other clinical parameters.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm13185597