Successful intrahepatic cholangiocarcinoma conversion surgery after administration of fibroblast growth factor receptor inhibitor

We describe a case of a 47-year-old male patient with initially unresectable intrahepatic cholangiocarcinoma of the right liver lobe with tumor thrombi extending from the right bile duct to the common and left bile ducts. Conventional chemotherapy with gemcitabine and cisplatin for 19 months resulte...

Full description

Saved in:
Bibliographic Details
Published in:Clinical journal of gastroenterology 2024-10, Vol.17 (5), p.936-942
Main Authors: Kaneko, Junichi, Kiuchi, Ryota, Takinami, Masaki, Ohnishi, Ippei, Ito, Jun, Jindo, Osamu, Nishino, Masafumi, Takahashi, Yurimi, Yamada, Takanori, Sakaguchi, Takanori
Format: Article
Language:English
Subjects:
Abdominal Surgery
Antineoplastic Agents - therapeutic use
Bile Duct Neoplasms - drug therapy
Bile Duct Neoplasms - surgery
Bile Ducts, Intrahepatic - surgery
Case Report
Cholangiocarcinoma - drug therapy
Cholangiocarcinoma - surgery
Colorectal Surgery
Gastroenterology
Hepatectomy - methods
Hepatology
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Morpholines
Pyrimidines - administration & dosage
Pyrimidines - therapeutic use
Pyrroles
Receptor, Fibroblast Growth Factor, Type 2 - antagonists & inhibitors
Receptor, Fibroblast Growth Factor, Type 2 - genetics
Surgical Oncology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We describe a case of a 47-year-old male patient with initially unresectable intrahepatic cholangiocarcinoma of the right liver lobe with tumor thrombi extending from the right bile duct to the common and left bile ducts. Conventional chemotherapy with gemcitabine and cisplatin for 19 months resulted in progressive disease. Subsequently, a comprehensive genome profile revealed fibroblast growth factor receptor 2 rearrangement, and hence, pemigatinib administration was initiated. After 6 months of pemigatinib therapy, significant shrinking of the tumor and disappearance of the tumor thrombi in the common and left bile duct were observed. Subsequently, the patient underwent conversion surgery, resulting in successful radical resection of the tumor. The patient has been disease-free for 7 months.
ISSN:1865-7257
1865-7265
1865-7265
DOI:10.1007/s12328-024-02014-w