The frequency content of common synaptic inputs to motoneurones studied during voluntary isometric contraction in man

• Published in: The Journal of physiology 1993-10, Vol.470 (1), p.127-155
• Main Authors: Farmer, S F, Bremner, F D, Halliday, D M, Rosenberg, J R, Stephens, J A
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biological and medical sciences; Cerebrovascular Disorders - physiopathology; Electromyography; Fundamental and applied biological sciences. Psychology; Hand - innervation; Humans; Isometric Contraction - physiology; Middle Aged; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration; Motor Neurons - physiology; Muscles - innervation; Neural Pathways - physiology; Neurons, Afferent - physiology; Synapses - physiology; Vertebrates: nervous system and sense organs
• ISSN: 0022-3751; 1469-7793
• DOI: 10.1113/jphysiol.1993.sp019851

1. The discharges of pairs of individual motor units were recorded from intrinsic hand muscles in man. Single motor unit recordings were obtained either when both members of the motor unit pair were within first dorsal interosseous muscle (1DI:1DI recordings) or where one motor unit was within 1DI and the other in second dorsal interosseous muscle (1DI:2DI recordings). The pairs of motor unit spike trains were cross-correlated in the time domain and the results compared to those of coherence analysis performed on the same spike train data. Central peaks were present in the cross-intensity functions, indicating the presence of common synaptic input to the motoneurone pair. Coherence analysis of these data indicated significant association between motor unit firing in the frequency ranges 1-12 and 16-32 Hz. 2. Analysis of sequential non-overlapping segments of data recorded from individual motor unit pairs, demonstrated that both the central cross-intensity peak and coherence in the frequency bands 1-12 and 16-32 Hz were consistent features throughout a long recording. In these sequential recordings, the size of the central cross-intensity peak and the maximal value of coherence in the frequency band 16-32 Hz covaried from segment to segment. Analysis of the entire population of motor unit pairs confirmed a positive relationship between the magnitude of peak coherence and the size of the central cross-intensity peak. 3. Voluntary sinusoidal co-modulation of the firing rates of pairs of individual motor units recorded from within 1DI was found to produce significant values of coherence corresponding to the frequency of the common modulation. However, firing rate co-modulation was not found to affect either the size of the central cross-intensity peak or the maximum value of coherence in the frequency band 16-32 Hz. 4. Pairs of single motor units were recorded from within 1DI and biceps brachii muscles of healthy subjects. The number and size of the central cross-intensity peaks and coherence peaks detected were compared for the two muscles. The incidence and size of central cross-intensity peaks and the incidence and magnitude of 16-32 Hz coherence peaks were both found to be greater for 1DI recordings when compared to biceps brachii recordings. 5. Single motor unit recordings were made from the intrinsic hand muscles of a patient with severe peripheral deafferentation. Time- and frequency-domain analysis of these recordings revealed cross-intensity peaks and